Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons.

Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Research Abstract Details 

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Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Abstract Text:

S F Vatner,G R Heyndrickx,J T Fallon,

The effects of 15 min periods of coronary occlusion on global and regional myocardial function, plasma creatine kinase (CK) and isoenzyme MB CK activity and subsequent myocardial necrosis were studied in 15 conscious dogs and 9 conscious baboons. Overall left ventricular (LV) function was assessed with measurements of LV systolic and diastolic pressures, rate of change of LV pressure, LV dP/dt. Regional LV function was assessed with measurements of regional segment length and velocity of shortening and/or regional LV wall thickening. An implanted hydraulic occluder on either the left anterior descending or circumflex coronary artery was inflated for 15 min. This induced complete loss of segment length shortening and systolic wall thickening (ultrasonic transit time technique). With release of the occlusion and reperfusion, recovery of regional mechanical function was delayed, but did occur after 6 hrs. Serial plasma enzyme activity revealed a significant increase in total CK as well as MB CK. At autopsy, neither gross pathological evidence (TTC-technique) nor histological evidence of myocyte necrosis was observed. Thus, in the conscious dog as well as in the conscious baboon, short episodes of intense myocardial ischemia do not result in a permanent deficit of myocardial function or necrosis. However, during the early phase of reperfusion, significant depression of regional mechanical function is observed associated with significant appearance of total CK and MB CK in the blood.

Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Publishing Authors By Initials

SF Vatner,GR Heyndrickx,JT Fallon,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Canadian journal of cardiology

VOLUME: Suppl A

Page Numbers: 19A-24A

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: Jul

YEAR: 1986

Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Information

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LANGUAGE: eng

NlmUniqueID: 8510280

Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pathology

Chemical & Substance for Abstract: Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Information

Substance Name: Creatine Kinase

Registry Number: EC 2.7.3.2

Grant and Affiliation Information for Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons.

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Country: CANADA

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MEDLINETA: Can J Cardiol

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