Effects of Botox and Neuronox on muscle force generation in mice.

Effects of Botox and Neuronox on muscle force generation in mice. Research Abstract Details 

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Effects of Botox and Neuronox on muscle force generation in mice. Abstract Text:

Austin V Stone,Jianjun Ma,Patrick W Whitlock,L Andrew Koman,Thomas L Smith,Beth P Smith,Michael F Callahan,Austin V Stone,Jianjun Ma,Patrick W Whitlock,L Andrew Koman,Thomas L Smith,Beth P Smith,Michael F Callahan,

The current study determined the dose-response relationship for inhibition of muscle force of two commercially available botulinum neurotoxin type-A (BoNTA) preparations (Botox and Neuronox) in a murine model and characterized the time course of recovery from the toxin-induced muscle paralysis. The effect of freezing reconstituted toxin on toxin potency was also determined. The gastrocnemius muscles in male CD-1 mice were injected with either saline or BoNTA (0.3-3.0 U/kg), and muscle force generation was examined following stimulation of the tibial nerve (single twitch and 15-200 Hz tetany). Botox and Neuronox produced nearly equivalent decrements in muscle force (30%-90%) at 4 days after toxin injection. At 28 days after injection (1 U/kg), muscle force had recovered from the effects of both toxin preparations. Maintaining reconstituted toxin at -80 degrees C for up to 5 months did not result in significant loss of toxin activity. The results of this study suggest that Botox and Neuronox produce equivalent responses in a murine model, and, in contrast to other models, muscle recovery is rapid with doses of toxin that produce less than maximal decrements in muscle force.

Effects of Botox and Neuronox on muscle force generation in mice. Publishing Authors By Initials

AV Stone,J Ma,PW Whitlock,LA Koman,TL Smith,BP Smith,MF Callahan,AV Stone,J Ma,PW Whitlock,LA Koman,TL Smith,BP Smith,MF Callahan,

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Effects of Botox and Neuronox on muscle force generation in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of orthopaedic research : official publica

VOLUME: 25

Page Numbers: 1658-64

Journal Abbreviation: J. Orthop. Res.

ISSN: 1554-527X

DAY: 20

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 8404726

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Grant and Affiliation Information for Effects of Botox and Neuronox on muscle force generation in mice.

AFFILIATION: Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

Country: United States

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MEDLINETA: J Orthop Res

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