Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report.

Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. Research Abstract Details 

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Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. Abstract Text:

H Orui,S Imaizumi,T Ogino,T Motoyama,

The effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on cell growth were studied in three human osteosarcoma cell lines, NOS-1, HuO9, and HuO-3N1; one human prostate cancer cell line, PC-3; and one human breast cancer cell line, OCUB-1M. The growth of these cell lines was not promoted by rhBMP-2 at concentrations of 50, 100, 250, and 500 ng/ml, as evaluated by colorimetric 3 (4,5-dimethyl-thiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay. Furthermore, the protein induced osteogenic differentiation, characterized by increased alkaline phosphatase activity, and increased production of type I collagen and gamma-carboxylated osteocalcin in NOS-1 cells. The results of this study may suggest the feasibility of using rhBMP-2 for the reconstruction of bone defects caused by malignant tumors, although the data are still preliminary and require further investigation.

Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. Publishing Authors By Initials

H Orui,S Imaizumi,T Ogino,T Motoyama,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of orthopaedic science : official journal

VOLUME: 5

Page Numbers: 600-4

Journal Abbreviation:

ISSN: 0949-2658

DAY: 19

MONTH: 11

YEAR: 2000

Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9604934

Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. Information

Substance Name: Alkaline Phosphatase

Registry Number: EC 3.1.3.1

Grant and Affiliation Information for Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report.

AFFILIATION: Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990-9585, Japan.

Country: Japan

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MEDLINETA: J Orthop Sci

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