Effects of bevacizumab on retinal function in isolated vertebrate retina.

Effects of bevacizumab on retinal function in isolated vertebrate retina. Research Abstract Details 

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Effects of bevacizumab on retinal function in isolated vertebrate retina. Abstract Text:

BACKGROUND: Bevacizumab (Avastin) is a recombinant protein that targets vascular endothelial growth factor (VEGF). In vitro, bevacizumab inhibits VEGF induced cell proliferation and tissue factor production. Abnormal angiogenesis involving VEGF is a central event during the development of choroidal neovascularisation (CNV). The present study was designed to evaluate the short term toxic effects of bevacizumab on retinal function for a therapeutic intraocular application. METHODS: Isolated bovine retinas were perfused with an oxygen pre-incubated nutrient solution. The electroretinogram (ERG) was recorded as a transretinal potential using silver/silver chloride electrodes. Bevacizumab was added in different concentrations to the nutrient solution for 45 minutes. Thereafter the retina was reperfused for 60 minutes with normal nutrient solution. The percentage of a-wave and b-wave reduction during the application of bevacizumab was calculated and compared to control recordings. RESULTS: During the application of three different concentrations of bevacizumab (0.08 mg/ml, 0.25 mg/ml, 0.8 mg/ml) no significant reduction of the a-wave and b-wave amplitude was observed. During the washout, the ERG amplitudes were unchanged. CONCLUSION: The present study suggests that an intraocular application of 0.25 mg/ml bevacizumab for the treatment of CNV is reasonable. No significant short term effects of bevacizumab on retinal function were detected, but long term effects cannot be excluded.

Effects of bevacizumab on retinal function in isolated vertebrate retina. Publishing Authors By Initials

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue culture techniques research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue culture techniques research

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Effects of bevacizumab on retinal function in isolated vertebrate retina. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 90

Page Numbers: 1178-82

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 5

MONTH: 06

YEAR: 2006

Effects of bevacizumab on retinal function in isolated vertebrate retina. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Effects of bevacizumab on retinal function in isolated vertebrate retina. Keywords Mesh Terms:

KEYWORDS: Tissue Culture Techniques

MESH TERMS: physiology

Chemical & Substance for Abstract: Effects of bevacizumab on retinal function in isolated vertebrate retina. Information

Substance Name: bevacizumab

Registry Number: 0

Grant and Affiliation Information for Effects of bevacizumab on retinal function in isolated vertebrate retina.

AFFILIATION: University Eye Hospital, Centre for Ophthalmology, Eberhard-KarlsUniversity of Tuebingen, Schleichstrasse 12-16, D-72076, Tuebingen, Germany. matthias.lueke@med.uni-tuebingen.de

Country: England

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MEDLINETA: Br J Ophthalmol

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