Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits.

Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits. Research Abstract Details 

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Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits. Abstract Text:

Bone grafts which have been supplemented with a growth factor might incorporate faster. In this study we investigated the effect of basic fibroblast growth factor (bFGF). Titanium bone harvest chambers were implanted bilaterally in the proximal tibia of rabbits. These chambers were pierced by a transverse bone ingrowth canal from which 1 x 1 x 5 mm cancellous bone rods were repeatedly harvested at 5 weeks intervals. The bone rods to be used as allografts were frozen as ordinary bank bone, and then lipid-extracted. This treatment yields a graft which elicits less of an immunologic response than allografts which are only frozen and thawed. Before implantation, the bone rods were soaked in a cellulose gel containing 0.5 microgram/ml recombinant human bFGF or gel without bFGF as a control. The grafts were then implanted pair wise (bFGF and control) in the chambers of recipient rabbits. These chambers were harvested after 2 weeks. Evaluation was made by Tc-MDP scintimetry, histomorphometry and histology. Upon histology new living tissue had filled the grafted chambers entirely and partly replaced the graft. bFGF induced an increased amount of pre-osteoblastic tissue in the bFGF-treated grafts (p < 0.02), but there was no difference in the amount of osteoid or new bone.

Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits. Publishing Authors By Initials

For similar proteins: recombinant proteins research abstracts see: proteins: recombinant proteins research

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Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annales chirurgiae et gynaecologiae. Supplementum

VOLUME: 207

Page Numbers: 129-35

Journal Abbreviation:

ISSN: 0355-9874

DAY: 26

MONTH: 02

YEAR: 1993

Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 7702959

Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits. Keywords Mesh Terms:

KEYWORDS: Recombinant Proteins

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits. Information

Substance Name: Fibroblast Growth Factor 2

Registry Number: 103107-01-3

Grant and Affiliation Information for Effects of basic fibroblast growth factor on bone allografts. A study using bone harvest chambers in rabbits.

AFFILIATION: Department of Orthopedics, Lund University Hospital, Sweden.

Country: FINLAND

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MEDLINETA: Ann Chir Gynaecol Suppl

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