Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways.

Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways. Research Abstract Details 

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Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways. Abstract Text:

H Yanagawa,F Egami,

1. The effects of lipoate and asparagusate on animal and plant enzymes of the TCA cycle and related metabolic pathways were studied. 2. Lipoate inhibited bovine liver glutamate dehydrogenase [EC 1.4.1.3]. The inhibition may play a role in metabolic regulation. 3. Asparagusate inhibited lipoyl dehydrogenase [EC 1.6.4.3] from asparagus and lettuce competitively with respect to lipoate. Asparagusate had practically no effects on other asparagus enzymes. 4. Asparagusate strongly inhibited lipoyl dehydrogenase, glutamate dehydrogenase, and isocitrate dehydrogenase [EC 1.1.1.42] from animal sources, in competition with the corresponding substrate. 5. Asparagusate and lipoate also inhibited yeast glutamate dehydrogenase. 6. Based upon kinetic studies, the mode of these inhibitions is discussed.

Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways. Publishing Authors By Initials

H Yanagawa,F Egami,

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Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 78

Page Numbers: 1153-60

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1975

Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways. Keywords Mesh Terms:

KEYWORDS: Thiophenes

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of asparagusate and lipoate on enzymes of the tricarboxylic acid cycle and related metabolic pathways. Information

Substance Name: Aconitate Hydratase

Registry Number: EC 4.2.1.3

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Country: JAPAN

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MEDLINETA: J Biochem

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