Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice.

Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. Research Abstract Details 

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Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. Abstract Text:

Kouki Mori,Katsumi Yoshida,Jun-Ichi Tani,Yoshinori Nakagawa,Saeko Hoshikawa,Hiroshi Ozaki,Sadayoshi Ito,Kouki Mori,Katsumi Yoshida,Jun-Ichi Tani,Yoshinori Nakagawa,Saeko Hoshikawa,Hiroshi Ozaki,Sadayoshi Ito,

We evaluated the effects of angiotensin II (Ang II) blockers, losartan, an Ang II receptor blocker, and enalapril, an angiotensin converting enzyme inhibitor, on the development of autoimmune thyroiditis in nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis (HT). Mice were assigned into three groups, untreated, losartan-treated (30 mg/kg/day), and enalapril-treated (10 mg/kg/day) groups. Thyroiditis was induced by iodide ingestion (experiment 1) or mouse thyroglobulin (Tg) immunization (experiment 2). Both procedures effectively induced thyroiditis. While iodide ingestion failed to induce anti-mouse Tg antibody (TgAb) production, Tg immunization resulted in a significant increase in serum TgAb levels. In both experiments, neither losartan nor enalapril interfered with the development of thyroiditis and TgAb production. These results suggest that Ang II may not be associated with the development of autoimmune thyroiditis in NOD mice. Thus, the Ang II blockade may not have therapeutic potential in HT.

Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. Publishing Authors By Initials

K Mori,K Yoshida,J Tani,Y Nakagawa,S Hoshikawa,H Ozaki,S Ito,K Mori,K Yoshida,J Tani,Y Nakagawa,S Hoshikawa,H Ozaki,S Ito,

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Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical immunology (Orlando, Fla.)

VOLUME: 126

Page Numbers: 97-103

Journal Abbreviation: Clin. Immunol.

ISSN: 1521-6616

DAY: 24

MONTH: 10

YEAR: 2007

Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. Information

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LANGUAGE: eng

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AFFILIATION: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Country: United States

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MEDLINETA: Clin Immunol

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