Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats.

Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. Research Abstract Details 

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Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. Abstract Text:

Hitoshi Masuda,Teruyuki Ogawa,Kazunori Kihara,Michael B Chancellor,William C de Groat,Naoki Yoshimura,

OBJECTIVE: To investigate the effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. MATERIALS AND METHODS: The effects of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthase, on bladder and urethral activities were evaluated by infusion cystometrography (CMG) and urethral perfusion pressure under isovolumetric conditions in awake or urethane-anaesthetized rats. L-NAME was administered intravenously (i.v.), intrathecally (i.t.), intracerebroventriculary (i.c.v.) or intravesically in normal rats or rats pre-treated with resiniferatoxin, a potent C-fibre afferent neurotoxin. RESULTS: L-NAME injected i.v. decreased the intercontraction interval (ICI) in the awake but increased it in the anaesthetized rats. L-NAME injected i.t. increased the ICI in both states and these effects were not apparent after pre-treatment with resiniferatoxin. L-NAME injected i.c.v. decreased the ICI in the awake but increased i.t. in the anaesthetized rats. Intravesical L-NAME decreased the ICI in the awake but not in the anaesthetized rats. L-NAME administered i.v., but not i.t. or i.c.v., increased bladder contraction during CMG. Under isovolumetric conditions, L-NAME administered i.v., but not i.t. or i.c.v., reduced the urethral relaxation without changing bladder contraction. CONCLUSIONS: These results indicate that spinal NO release facilitates the mechanoceptive C-fibres, and this facilitatory effect is masked by supraspinal (possibly forebrain) and local inhibitory effects of NO during the micturition reflex in awake rats. Urethane seems to inhibit the supraspinal and local inhibitory effects of NO, resulting in unmasking the facilitatory effect of NO in the spinal cord and brain stem. During the voiding phase, urethral relaxation depends on the peripheral but not the central NO system.

Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. Publishing Authors By Initials

H Masuda,T Ogawa,K Kihara,MB Chancellor,WC de Groat,N Yoshimura,

For similar reproductive and urinary physiology: urinary tract physiology: urination research abstracts see: reproductive and urinary physiology: urinary tract physiology: urination research

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Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: BJU international

VOLUME: 100

Page Numbers: 175-80

Journal Abbreviation: BJU Int.

ISSN: 1464-4096

DAY: 4

MONTH: 05

YEAR: 2007

Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886721

Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. Keywords Mesh Terms:

KEYWORDS: Urination

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. Information

Substance Name: Nitric Oxide Synthase

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats.

AFFILIATION: Department of Urology and Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. hi-masu.uro@tmd.ac.jp

Country: England

AGENCY: United States NICHD

GRANT: P01 HD 39768

ACRONYM: HD

MEDLINETA: BJU Int

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