Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen.

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Abstract Text:

Le Zhang,Feng Li,Edgardo Dimayuga,Jeffrey Craddock,Jeffrey N Keller,Le Zhang,Feng Li,Edgardo Dimayuga,Jeffrey Craddock,Jeffrey N Keller,Le Zhang,Feng Li,Edgardo Dimayuga,Jeffrey Craddock,Jeffrey N Keller,

In the present study, we demonstrate for the first time that aging increases the levels of ubiquitinated protein in the spleen, and that dietary restriction (DR) significantly reduces these age-related increases in ubiquitinated protein. Sumoylated protein, proteasome subunits, and a protein essential for proteasome biogenesis (POMP1) were also increased with age in the spleen but were not significantly affected by DR. Chymotrypsin-like proteasome activity was elevated in the aged spleen, and was not significantly altered by DR. Together, these data demonstrate for the first time the multiple effects of aging and DR on ubiquitination, sumoylation, and the proteasome in the spleen.

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Publishing Authors By Initials

L Zhang,F Li,E Dimayuga,J Craddock,JN Keller,L Zhang,F Li,E Dimayuga,J Craddock,JN Keller,L Zhang,F Li,E Dimayuga,J Craddock,JN Keller,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 581

Page Numbers: 5543-7

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 6

MONTH: 11

YEAR: 2007

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 155157

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen.

AFFILIATION: Sanders-Brown Center on Aging, 205 Sanders-Brown, 800 South Limestone, University of Kentucky, Lexington, KY 40536-0230, USA.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: FEBS Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen Related Publications

• A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates.
• Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.
• Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management.
• BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
• Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells.
• Candicine from Stapelia gigantea.
• Children's skin conductance reactivity as a mechanism of risk in the context of parental depressive symptoms.
• Comparison of extracellular and intracellular potency of botulinum neurotoxins.
• Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
• Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.
• Drosophila melanogaster's history as a human commensal.
• Effect of glucocorticoid-induced osteoporotic-like conditions on osteoblast cell attachment to implant surface microtopographies.
• Effect of operational parameters on the recovery rate of an oleophilic drum skimmer.
• Flagellar elongation and gene expression in Chlamydomonas reinhardtii.
• GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.
• Illegitimate recombination is a major evolutionary mechanism for initiating size variation in plant resistance genes.
• Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease.
• Metabolic pathway engineering in cotton: Biosynthesis of polyhydroxybutyrate in fiber cells.
• Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
• Production of targeted poly(3-hydroxyalkanoates) copolymers by glycogen accumulating organisms using acetate as sole carbon source.
• Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness.
• Reproductive isolation between Pogonomyrmex rugosus and two lineages with genetic caste determination.
• Secondary metabolic gene cluster silencing in Aspergillus nidulans.
• Short telomeres in short-lived males: what are the molecular and evolutionary causes?
• The presumptive floor plate (notoplate) induces behaviors associated with convergent extension in medial but not lateral neural plate cells of Xenopus.
• The role of Wnts in bone metastases.
• The whisking rhythm generator: a novel mammalian network for the generation of movement.
• Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.
• What impact, if any, has feminism had on science?
• [Extraction of thermolabile compounds with supercritical gases.]