Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging.

Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. Research Abstract Details 

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Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. Abstract Text:

David L Levin,Richard B Buxton,James P Spiess,Tatsuya Arai,Jamal Balouch,Susan R Hopkins,

Normal aging is associated with a decline in pulmonary function and efficiency of gas exchange, although the effects on the spatial distribution of pulmonary perfusion are poorly understood. We hypothesized that spatial pulmonary perfusion heterogeneity would increase with increasing age. Fifty-six healthy, nonsmoking subjects (ages 21-76 yr) underwent magnetic resonance imaging with arterial spin labeling (ASL) using a Vision 1.5-T whole body scanner (Siemens Medical Systems, Erlangen, Germany). ASL uses a magnetically tagged bolus to generate perfusion maps where signal intensity is proportional to regional pulmonary perfusion. The spatial heterogeneity of pulmonary blood flow was quantified by the relative dispersion (RD = SD/mean, a global index of heterogeneity) of signal intensity for voxels within the right lung and by the fractal dimension (D(s)). There were no significant sex differences for RD (P = 0.81) or D(s) (P = 0.43) when age was considered as a covariate. RD increased significantly with increasing age by approximately 0.1/decade until age 50-59 yr, and there was a significant positive relationship between RD and age (R = 0.48, P < 0.0005) and height (R = 0.39, P < 0.01), but not body mass index (R = 0.07, P = 0.67). Age and height combined in a multiple regression were significantly related to RD (R = 0.66, P < 0.0001). There was no significant relationship between RD and spirometry or arterial oxygen saturation. D(s) was not related to age, height, spirometry, or arterial oxygen saturation. The lack of relationship between age and D(s) argues against an intrinsic alteration in the pulmonary vascular branching with age as being responsible for the observed increase in global spatial perfusion heterogeneity measured by the RD.

Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. Publishing Authors By Initials

DL Levin,RB Buxton,JP Spiess,T Arai,J Balouch,SR Hopkins,

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Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 102

Page Numbers: 2064-70

Journal Abbreviation:

ISSN: 8750-7587

DAY: 15

MONTH: 02

YEAR: 2007

Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. Information

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LANGUAGE: eng

NlmUniqueID: 8502536

Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. Keywords Mesh Terms:

KEYWORDS: Spin Labels

MESH TERMS: methods

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Substance Name: Spin Labels

Registry Number: 0

Grant and Affiliation Information for Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging.

AFFILIATION: Department of Radiology, University of California, San Diego, La Jolla, CA 92093-0623, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M01RR-00827

ACRONYM: RR

MEDLINETA: J Appl Physiol

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