Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers.

Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Research Abstract Details 

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Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Abstract Text:

Masaki Sanaka,Takatsugu Yamamoto,Hajime Anjiki,Kunitaka Nagasawa,Yasushi Kuyama,

1. Dietary fibre, such as pectin, delays gastric emptying and may enhance post-prandial glucose tolerance. Agar, which is high in fibre content, is widely used in the traditional Japanese diet. Although long-term diet therapy with agar decreases fasting plasma glucose levels in diabetes, knowledge is lacking about the acute effects of agar on gastric emptying and the post-prandial glycaemic profiles. The present study was designed to investigate the acute effects of agar. 2. Ten healthy male volunteers were studied on three occasions with three different test meals (450 kcal/500 mL): (i) a fibre-free meal; (ii) a meal with 2.0 g agar; or (iii) a meal with 5.2 g pectin. On each occasion, participants underwent a [(13)C]-acetate breath test along with serial blood sampling. To quantify gastric emptying, the half [(13)CO(2)] excretion time (t((1/2)b)) and the time for maximal [(13)CO(2)] excretion rate (t(lag)) were determined. The post-prandial glycaemic response was expressed as an incremental change from the fasting value at each sampling time. Data were analysed using repeated-measures analysis of variance (anova), followed by a post hoc paired Student's t-test with Bonferroni adjustment. 3. The time-course for respiratory [(13)CO(2)] excretion differed significantly among the three test meals (P = 0.0004, anova). Compared with the control meal, [(13)CO(2)] excretion was significantly lower following consumption of the agar meal (between 40 and 105 min post-prandially; P < 0.025, Student's t-test) and the pectin meal (between 40 and 180 min post-prandially; P < 0.025, Student's t-test). Among the three meals, significant differences were found in t((1/2)b) (P = 0.002, anova) and t(lag) (P = 0.011, anova). Compared with the control meal, the agar and pectin meals exhibited a significantly prolonged t((1/2)b) (P = 0.007 and P < 0.0001, respectively, Student's t-test) and t(lag) (P = 0.006 and P = 0.002, respectively, Student's t-test). Neither the agar nor pectin meal affected the post-prandial glucose profile. 4. In healthy adults, agar and pectin delay gastric emptying but have no impact on the post-prandial glucose response.

Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Publishing Authors By Initials

M Sanaka,T Yamamoto,H Anjiki,K Nagasawa,Y Kuyama,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Clinical and experimental pharmacology & physiolog

VOLUME: 34

Page Numbers: 1151-5

Journal Abbreviation: Clin. Exp. Pharmacol. Physiol.

ISSN: 0305-1870

DAY: 3

MONTH: Nov

YEAR: 2007

Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Information

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LANGUAGE: eng

NlmUniqueID: 425076

Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Information

Substance Name: Agar

Registry Number: 9002-18-0

Grant and Affiliation Information for Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers.

AFFILIATION: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan. sanaka.koma.@cick.jp

Country: Australia

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MEDLINETA: Clin Exp Pharmacol Physiol

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