Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression.

Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. Abstract Text:

Cushing's disorder and depression present overlapping although not identical psychological symptomatology. In turn, a subset of patients with affective disorders present with hypercortisolemia and disturbances, specifically disinhibition, of the hypothalamic hypophysio adrenal axis (HHAA). Memory disturbances, in particular, biasing toward negative contents, overlapping sleep abnormalities (marked reduction of stages 3 and 4) increased fatigue and loss of energy, attentional deficits and irritability, are just part of the common symptomatology presented by patients with both Cushing's disorder and depression. All of these behavioral manifestations are known to be affected by adrenal steroid hormones. There is consensus that hippocampal structures are a main target for adrenal steroid hormones; hence, these neural regions are some of the most likely mediators of the effects of corticoadrenal steroids on behavior. This paper proposes that an imbalance of adrenal steroids and their metabolites may play a fundamental role in the psychophysiopathology of Cushing's and depressive disorders. The imbalance of these hormones, especially at limbic sites, could distort mood and memory content affecting cognition based on recollection and present experiences. Reestablishing an adrenal balance could therefore be considered as a therapeutic aid in a subset of depressive disorders.

Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. Publishing Authors By Initials

For similar nervous system diseases: sleep disorders research abstracts see: nervous system diseases: sleep disorders research

PUBMED ID PMID:

MEDLINE DATE:

Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 18

Page Numbers: 4-16

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: Jan

YEAR: 1993

Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. Information

Number of References: 175

LANGUAGE: eng

NlmUniqueID: 9107859

Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. Keywords Mesh Terms:

KEYWORDS: Sleep Disorders

MESH TERMS: etiology

Chemical & Substance for Abstract: Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. Information

Substance Name: Adrenal Cortex Hormones

Registry Number: 0

Grant and Affiliation Information for Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression.

AFFILIATION: McGill University Medical School, Montreal, Quebec, Canada.

Country: CANADA

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Psychiatry Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression Related Publications

• Adrenal steroids and the physiopathology of a subset of depressive disorders.
• Determinate root growth and meristem maintenance in angiosperms.
• Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression.
• Ethylene-auxin interactions regulate lateral root initiation and emergence in Arabidopsis thaliana.
• Evolution of nervous systems and psychiatry: consequences of the vertical and horizontal duality of the evolutionary process.
• Impairments in limb actions after dorsal funiculi section in cats.
• Quantum dots in flow cytometry.
• Regional nitrate and pesticide trends in ground water in the eastern San Joaquin Valley, California.
• Subclinical sensory abnormalities in trigeminal neuralgia.
• [Not Available.]
• [Studies on placenta and its relation to blastomatosis.]