Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers.

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers. Abstract Text:

Brian Hitsman,James Mackillop,Anne Lingford-Hughes,Tim M Williams,Faheem Ahmad,Sally Adams,David J Nutt,Marcus R Munafò,

RATIONALE: Acute tyrosine/phenylalanine depletion (ATPD) is a validated neurobiological challenge that results in reduced dopaminergic neurotransmission, allowing examination of the effects of a hypodopaminergic state on craving-related processes. OBJECTIVES: We studied 16 nonabstaining smokers (>10 cigarettes/day; 9 males; age 20-33 years) to whom was administered a tyrosine/phenylalanine-free mixture (TYR/PHE-free) and a balanced amino acid mixture (BAL) in a double-blind, counterbalanced, crossover design. METHODS: Subjective cigarette craving, attentional bias to smoking-related word cues, relative value of cigarettes, negative mood, and expired carbon monoxide (CO) levels were measured at various timepoints through 300 min. Participants smoked at hourly intervals to prevent acute nicotine withdrawal during testing. RESULTS: The TYR/PHE-free mixture, as compared to the BAL mixture, was associated with a greater increase in CO levels from baseline (p = 0.01). Adjusting for the potential confounding influence of between-condition differences in CO levels across time, TYR/PHE-free mixture was associated with increased demand for cigarettes (p = 0.01) and decreased attentional bias toward smoking-related words (p = 0.003). There were no significant differences between conditions in either subjective craving or depressed or anxious mood (p values > 0.05). CONCLUSION: Among nonabstaining daily smokers, acute dopaminergic depletion via ATPD may influence smoking behavior and indices of smoking-related motivation, such as attentional bias to smoking cues and relative cigarette value, which are not readily captured by subjective craving.

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers. Publishing Authors By Initials

B Hitsman,J Mackillop,A Lingford-Hughes,TM Williams,F Ahmad,S Adams,DJ Nutt,MR Munafò,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychopharmacology

VOLUME: 196

Page Numbers: 611-21

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 25

MONTH: 11

YEAR: 2007

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers.

AFFILIATION: Centers for Behavioral and Preventive Medicine, The Miriam Hospital and Brown Medical School, Coro Building, Suite 500, 1 Hoppin Street, Providence, RI, 02903, USA, brian_hitsman@brown.edu.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Psychopharmacology (Berl)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers Related Publications

• A cost-effectiveness analysis of genetic testing of the DRD2 Taq1A polymorphism to aid treatment choice for smoking cessation.
• Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial.
• Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study.
• Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers.
• Forum: interactions between gene and environment.
• Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: New data from the Patch in Practice trial and pooled analyses.
• Genetics and smoking cessation improving outcomes in smokers at risk.
• Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.
• Smoking cessation in primary care.