Effects of acute and chronic L-arginine treatment in experimental hyperuricemia.

Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Research Abstract Details 

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Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Abstract Text:

Laura G ,Edilia Tapia, , Nepomuceno,Virgilia Soto,Carmen Avila-Casado,Takahiko Nakagawa,Richard J Johnson,Jaime Herrera-Acosta,Martha Franco,

Experimental hyperuricemia (HU) results in preglomerular arteriolopathy, cortical vasoconstriction, and glomerular hypertension. Recently, uric acid has been shown to induce endothelial dysfunction. We therefore studied the effect of acute and chronic administration of l-arginine (a substrate for endothelial nitric oxide synthase) on the renal hemodynamic and vascular structural alterations induced by HU. To induce HU, oxonic acid (OA; 750 mg.kg(-1).day(-1)) was administered in male Sprague-Dawley rats. To study the acute effect of arginine, nine rats received l-arginine (l-Arg; 15 mg.kg(-1).min(-1)) during micropuncture. To elucidate the chronic effect of l-Arg, OA + 1% l-Arg (n = 8) and OA + 2.5% l-Arg (n = 6; drinking water) were evaluated throughout the 5-wk period. Eight normal control (N), and eight OA, rats were also studied. Kidneys were fixed by perfusion and afferent arteriole morphology was evaluated. HU rats developed the renal functional and structural alterations described and had suppressed urinary excretion of NO(2)(-)/NO(3)(-). Acute stimulation of nitric oxide (NO) synthesis markedly increased urinary NO(2)(-)/NO(3)(-), lowered systemic blood pressure, and relieved cortical vasoconstriction despite a significant increment of glomerular hypertension and afferent arteriole damage. Increasing doses of chronic l-Arg were associated with increasing excretion of urinary NO(2)(-)/NO(3)(-), reduction of systemic hypertension, and prevention of cortical vasoconstriction (2.5% l-Arg). In addition, both doses prevented glomerular hypertension and preglomerular arteriolopathy. Thus an acute relief of renal vasoconstriction in the setting of afferent arteriole damage cannot reverse glomerular hypertension, likely due to impairment in preglomerular autoregulation. On the other hand, chronic l-Arg preserved arteriolar structures probably mediated by the antiproliferative effect of NO on vascular smooth muscle cells.

Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Publishing Authors By Initials

LG ,E Tapia,R ,T Nepomuceno,V Soto,C Avila-Casado,T Nakagawa,RJ Johnson,J Herrera-Acosta,M Franco,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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MEDLINE DATE:

Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F1238-44

Journal Abbreviation:

ISSN: 0363-6127

DAY: 26

MONTH: 12

YEAR: 2006

Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901990

Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: urine

Chemical & Substance for Abstract: Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Information

Substance Name: Oxonic Acid

Registry Number: 937-13-3

Grant and Affiliation Information for Effects of acute and chronic L-arginine treatment in experimental hyperuricemia.

AFFILIATION: Dept. of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1. 14080, Mexico City, Mexico. lgsanchezlozada@hotmail.com

Country: United States

AGENCY: United States NHLBI

GRANT: HL-68607

ACRONYM: HL

MEDLINETA: Am J Physiol Renal Physiol

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