Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats.

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats. Abstract Text:

L F Solheim,H Rönningen,E Barth,N Langeland,

Antigen-extracted, autolyzed, demineralized bone matrix and bone matrix combined with isogeneic bone marrow (i.e., a composite graft) were placed in the musculature of young male rats. The influence of acetylsalicylic acid (ASA) on the osteogenic potential of these bone-inducing materials was studied during an 18-day period. ASA (150 mg/kg/12 h) was used to obtain anti-inflammatory serum levels comparable with those in humans. Resorption of the implanted matrix and new formation of bone were quantified using collagen- and mineral-tracing radioisotopes and collagen and calcium analyses. The matrix implants showed a slow tissue turnover and produced only small amounts of new bone, with no significant differences between ASA-treated and control rats. However, during the last 24 h of the study the ASA-treated implants had a significantly hampered rate of new bone formation. The tissue turnover and new bone yield, as well as the rate of new bone formation, increased in the control composite grafts but not in the ASA-treated composite grafts. Thus, the results indicate an inhibitory effect of ASA on the bone-forming capacity of bone marrow.

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats. Publishing Authors By Initials

LF Solheim,H Rönningen,E Barth,N Langeland,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

PUBMED ID PMID:

MEDLINE DATE:

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of orthopaedic and traumatic surgery. Arc

VOLUME: 106

Page Numbers: 140-3

Journal Abbreviation:

ISSN: 0344-8444

DAY: 21

MONTH: 02

YEAR: 1987

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7803037

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats.

AFFILIATION:

Country: GERMANY, WEST

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arch Orthop Trauma Surg

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats Related Publications

• Antibiotic prophylaxis in total hip arthroplasty. Review of 10,905 primary cemented total hip replacements reported to the Norwegian arthroplasty register, 1987 to 1995.
• BIOLOGIC TESTS IN EVALUATING DENTAL MATERIALS.
• CRITERIA FOR EVALUATION OF PULP REACTIONS TO CAVITY AND CROWN PREPARATION.
• Cutting procedures with minimized trauma.
• Debate: Is N2 an acceptable method of treatment?
• Demographics of Giardia infections in Bergen, Norway, subsequent to a waterborne outbreak.
• Effects of a distal venting hole in the femur during total hip replacement.
• Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats.
• Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur.
• Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats.
• Extended-spectrum beta-lactamase-type SHV-12-producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance.
• Mechanical properties of bone and skin during recovery after cyclophosphamide administration.
• Periradicular curettage.
• Persisting symptoms and duodenal inflammation related to Giardia duodenalis infection.
• Problems of intradental testing of restorative materials.
• Recurrent dislocation of patella following lateral retinacular release. A case report.
• The influence of oestrogen on bone metabolism.
• The need for biological evaluation of dental materials.
• Treatment-ladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway.
• Use of radioactive tracers to determine the protective effect of cavity liners.
• Yersinia enterocolitica and Yersinia enterocolitica-like bacteria in drinking water and sewage sludge.
• [AN INVESTIGATION OF THE RELATIONS BETWEEN ORAL HYGIENE AND DISEASE.]
• [Biological tests to estimate the value of dental materials]
• [Herpes gestationis. A dermatosis with consequences for further pregnancies]
• [Hygienic conditions of municipal sludge]
• [In Process Citation]
• [Interdisciplinary working teams--better for both the patients and the staff]
• [Neomycin. An aminoglycoside in the study of signal processing]
• [Pathology and pathogenesis in postmenopausal osteoporosis]
• [Unreasonable PR-campaign of the Norwegian Radium Hospital on the treatment of basalioma]