Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur.

Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur. Research Abstract Details 

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Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur. Abstract Text:

L F Solheim,H Rönningen,N Langeland,

The influence of acetylsalicylic acid (ASA) and naproxen on the biochemical properties of intact growing femora in young male rats was studied. The medication periods were 9 and 18 days. At an ASA dose of 150 mg/kg/12 h the rate of collagen synthesis and the rate of mineral incorporation decreased and were impaired by about 10% compared with controls after 18 days. The dry weights and contents of collagen and calcium were not influenced after 9 days, but were reduced by 4%-7% after 18 days. A higher solubility of collagen (7%) was also found at the end of the study. In rats that received ASA at 100 mg/kg/12 h no significant differences were observed. A naproxen dose of 20 mg/kg/12 h reduced the rate of mineral deposition after 18 days, but had no other detectable effects on bone. The results indicate that ASA inhibits bone formation.

Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur. Publishing Authors By Initials

LF Solheim,H Rönningen,N Langeland,

For similar natural sciences: chemistry: chemistry, physical: solubility research abstracts see: natural sciences: chemistry: chemistry, physical: solubility research

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Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of orthopaedic and traumatic surgery. Arc

VOLUME: 105

Page Numbers: 1-4

Journal Abbreviation:

ISSN: 0344-8444

DAY: 21

MONTH: 02

YEAR: 1986

Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7803037

Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur. Keywords Mesh Terms:

KEYWORDS: Solubility

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur.

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Country: GERMANY, WEST

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MEDLINETA: Arch Orthop Trauma Surg

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