Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats.

Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats. Research Abstract Details 

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Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats. Abstract Text:

L F Solheim,H Rönningen,N Langeland,

The influence of acetylsalicylic acid (ASA) and naproxen on growing bones was studied. Young male rats were used. The drugs were administered via gastric gavage twice a day for 9 or 18 days. Drug doses giving serum concentrations corresponding to ordinary anti-inflammatory steady-state levels in humans were used. There was a drug-related influence on the strength of the growing femur. After 9 days the ultimate bending moment of the distal femoral epiphyseal plate and ultimate torsional moment and stress of the femoral diaphysis increased by about 10% in the rats treated with 150 mg/kg/12 h of ASA as compared with controls. After 18 days there were no differences. The ultimate metaphyseal bending moment of the distal femur was not influenced after 9 days with this dose, but was reduced by about 10% compared with controls after 18 days. Doses of 100 mg/kg/12 h of ASA and 20 mg/kg/12 h of naproxen did not change the bone strength. The doses used were well tolerated and did not influence the bone growth or body weight of the rats. A naproxen dose of 40 mg/kg/12 h was lethal; rats that received this dose succumbed to jejunal perforations. The results indicate that ASA influences the remodeling of normally growing bones.

Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats. Publishing Authors By Initials

LF Solheim,H Rönningen,N Langeland,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of orthopaedic and traumatic surgery. Arc

VOLUME: 105

Page Numbers: 5-10

Journal Abbreviation:

ISSN: 0344-8444

DAY: 21

MONTH: 02

YEAR: 1986

Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats. Information

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LANGUAGE: eng

NlmUniqueID: 7803037

Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats. Information

Substance Name: Aspirin

Registry Number: 50-78-2

Grant and Affiliation Information for Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats.

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Country: GERMANY, WEST

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MEDLINETA: Arch Orthop Trauma Surg

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