Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls.

Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls. Research Abstract Details 

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Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls. Abstract Text:

Quantitative EEG (qEEG) was evaluated in Alzheimer's disease (AD) patients and age-matched controls following the administration of a single acute intravenous dose of scopolamine. Eleven AD patients and 8 cognitively intact age-matched controls underwent qEEG in baseline conditions, following double-blind intravenous administration of 0.5 mg scopolamine or placebo. At baseline, AD patients had significantly decreased absolute and relative alpha and increased relative theta amplitudes. In both groups, scopolamine administration was followed by a decrease in absolute and relative alpha amplitude, and increase in the absolute and relative delta activity. The increase in the absolute and relative delta amplitude by scopolamine was significantly more prominent in the controls; the decrease of alpha activity, while larger in controls, was not statistically different from AD. We conclude that scopolamine affects the change in delta amplitude differently in AD patients and controls, probably reflecting the reduced cholinergic tone in AD.

Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls. Publishing Authors By Initials

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Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Electroencephalography and clinical neurophysiolog

VOLUME: 91

Page Numbers: 407-12

Journal Abbreviation: Electroencephalogr Clin Neurop

ISSN: 0013-4694

DAY: 9

MONTH: Dec

YEAR: 1994

Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375035

Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls. Keywords Mesh Terms:

KEYWORDS: Scopolamine

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls. Information

Substance Name: Scopolamine

Registry Number: 51-34-3

Grant and Affiliation Information for Effects of a single intravenous dose of scopolamine on the quantitative EEG in Alzheimer's disease patients and age-matched controls.

AFFILIATION: Department of Neurology, Tel-Aviv Sourasky Medical Center, Israel.

Country: IRELAND

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MEDLINETA: Electroencephalogr Clin Neurop

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