Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis.

Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. Abstract Text:

Sachiko Matsuzaki,Michel Canis,Claude Darcha,Pierre J ,Jean-Luc Pouly, Mage,Sachiko Matsuzaki,Michel Canis,Claude Darcha,Pierre J ,Jean-Luc Pouly, Mage,Sachiko Matsuzaki,Michel Canis,Claude Darcha,Pierre J ,Jean-Luc Pouly, Mage,

OBJECTIVE: To evaluate the effect of protein kinase C inhibition on surgically induced endometriosis in mice. DESIGN: Prospective, randomized study. SETTING: Academic facility. ANIMALS: Sixty adult female C57BJ6 mice. INTERVENTION(S): On day -7, oral gavage of a vehicle alone or of a protein kinase C inhibitor (100 mg/kg/day, once a day) was started and continued for 1 week in donor groups A and B, respectively. On day 0, uterine fragments from donor group A were implanted into recipient mice. Recipient mice were divided randomly into two groups: group 1 (vehicle) and group 2 (protein kinase C inhibitor). Uterine fragments from donor group B were implanted into recipient mice, and they were divided randomly into two groups: group 3 (vehicle) and group 4 (protein kinase C inhibitor). Oral gavage of a protein kinase C inhibitor (100 mg/kg/day, once a day) or vehicle was continued for 1 week. MAIN OUTCOME MEASURE(S): Presence and number of ectopic implants. RESULT(S): The number of mice that developed ectopic implants was significantly lower in groups 3 (40%) and 4 (30%) than in group 1 (100%). The number of ectopic implants was significantly lower in groups 2, 3, and 4 than in group 1. CONCLUSION(S): Protein kinase C inhibitor use partially prevented the development of ectopic implants in a mouse model of endometriosis.

Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. Publishing Authors By Initials

S Matsuzaki,M Canis,C Darcha,PJ ,JL Pouly,G Mage,S Matsuzaki,M Canis,C Darcha,PJ ,JL Pouly,G Mage,S Matsuzaki,M Canis,C Darcha,PJ ,JL Pouly,G Mage,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Fertility and sterility

VOLUME: 89

Page Numbers: 206-11

Journal Abbreviation: Fertil. Steril.

ISSN: 1556-5653

DAY: 3

MONTH: 05

YEAR: 2007

Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372772

Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis.

AFFILIATION: Université d'Auvergne-Clermont I, Centre d'Endoscopie et des Nouvelles Techniques Interventionnelles, Clermont-Ferrand, France; CHU Clermont-Ferrand, Polyclinique-Hôtel-Dieu, Gynécologie Obstétrique et Médecine de la Reproduction, Clermont-Ferrand, France

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Fertil Steril

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis Related Publications

• Complete laparoscopic treatment of genital prolapse with meshes including vaginal promontofixation and anterior repair: a series of 138 patients.
• Early history of the American Society for the Study of Orthodontics.
• Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis.
• Effects of supplemental perioperative oxygen on post-operative abdominal wound adhesions in a mouse laparotomy model with controlled respiratory support.
• Future endoscopic trends in gynecological oncology.
• Genetic contributions to the autoantibody profile in a rabbit model of systemic lupus erythematosus (SLE).
• Hysterectomy for benign disease.
• Migration of filshie clip inside a small peritoneal defect.
• OP04.01: Magnetic resonance determiation of pH, lactates and oxymetry in animal model of acute fetal distress: Towards new ways of fetal monitoring?
• The correct application of Mage's Johnson SB procedure for fitting exposure data.
• Total laparoscopic hysterectomy and early discharge: satisfaction and feasibility study.
• [Autoimmune hepatitis and pregnancy: about a patient's three consecutive pregnancies.]
• [Endoscopic management of gynecological malignancies: an update]
• [Not Available.]
• [Not Available.]
• [Peritoneum and laparoscopic environment]