Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro.

Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro. Research Abstract Details 

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Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro. Abstract Text:

F Zhang,X Lu,V S Kumar,H Zhu,H Chen,Z Chen,J Hong,

A monoclonal antibody (mAb) 3C2, against an exospore protein of the microsporidium Nosema bombycis (N. bombycis) was prepared, and its effects on microsporidial germination and reproduction in vitro were studied. MAb 3C2 was effective in inhibiting the germination and subsequent infection of Bombyx mori cells compared to the control mAb. The antigen was isolated by 2-dimensional gel electrophoresis. Immunoblotting revealed it to be an 84 kDa protein corresponding to pI (7.2) on the 2-D gel. The present results suggest that the antibodies can be used for diagnostic purposes and for developing new therapeutic strategies in controlling microsporidian diseases.

Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro. Publishing Authors By Initials

F Zhang,X Lu,VS Kumar,H Zhu,H Chen,Z Chen,J Hong,

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Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Parasitology

VOLUME: 134

Page Numbers: 1551-8

Journal Abbreviation: Parasitology

ISSN: 0031-1820

DAY: 19

MONTH: 06

YEAR: 2007

Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 401121

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Grant and Affiliation Information for Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro.

AFFILIATION: Laboratory of Invertebrate Pathology, Zhejiang University, Hangzhou 310029, China.

Country: England

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MEDLINETA: Parasitology

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