Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model.

Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Research Abstract Details 

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Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Abstract Text:

Since the advent of cyclooxygenase 2 (COX-2) inhibitors, little research has been done on the effects of these medications on fracture healing. In the study reported here, we sought to determine whether a COX-2 inhibitor, celecoxib, affects strength and amount of healing callus formed after a fracture. Forty-eight male Sprague-Dawley rats were evaluated for impairment of fracture healing with celecoxib use. Compared with controls, celecoxib-treated rats had a significant decrease in force required for refracture (P = .0199). We do not recommend routine use of celecoxib in postfracture pain control, particularly when fracture union is tenuous.

Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Publishing Authors By Initials

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Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of orthopedics (Belle Mead, N.J.)

VOLUME: 37

Page Numbers: E133-7

Journal Abbreviation: Am J. Orthop.

ISSN: 1934-3418

DAY: 16

MONTH: Jul

YEAR: 2008

Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Information

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LANGUAGE: eng

NlmUniqueID: 9502918

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Grant and Affiliation Information for Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model.

AFFILIATION: Department of Orthopaedic Surgery, Wright State University School of Medicine, Dayton, OH, 45409, USA. maherbenick@mvh.org.

Country: United States

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MEDLINETA: Am J Orthop

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