Effector proteins translocated by Legionella pneumophila: strength in numbers.

Effector proteins translocated by Legionella pneumophila: strength in numbers. Research Abstract Details 

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Effector proteins translocated by Legionella pneumophila: strength in numbers. Abstract Text:

Shira Ninio,Craig R Roy,

The Gram-negative bacterium Legionella pneumophila is a parasite of eukaryotic cells. It has evolved to survive and replicate in a wide range of protozoan hosts and can also infect human alveolar macrophages as an opportunistic pathogen. Crucially for the infection process, L. pneumophila uses a type IV secretion system called Dot/Icm to translocate bacterial proteins into host cells. In recent years a large number of Dot/Icm-translocated proteins have been identified. The study of these proteins, referred to as effectors, is providing valuable insight into the mechanism by which an intracellular pathogen can manipulate eukaryotic cellular processes to traffic and replicate in host cells.

Effector proteins translocated by Legionella pneumophila: strength in numbers. Publishing Authors By Initials

S Ninio,CR Roy,

For similar cells: connective tissue cells: macrophages: macrophages, alveolar research abstracts see: cells: connective tissue cells: macrophages: macrophages, alveolar research

PUBMED ID PMID:

MEDLINE DATE:

Effector proteins translocated by Legionella pneumophila: strength in numbers. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in microbiology

VOLUME: 15

Page Numbers: 372-80

Journal Abbreviation: Trends Microbiol.

ISSN: 0966-842X

DAY: 13

MONTH: 07

YEAR: 2007

Effector proteins translocated by Legionella pneumophila: strength in numbers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9310916

Effector proteins translocated by Legionella pneumophila: strength in numbers. Keywords Mesh Terms:

KEYWORDS: Macrophages, Alveolar

MESH TERMS: microbiology

Chemical & Substance for Abstract: Effector proteins translocated by Legionella pneumophila: strength in numbers. Information

Substance Name: Bacterial Proteins

Registry Number: 0

Grant and Affiliation Information for Effector proteins translocated by Legionella pneumophila: strength in numbers.

AFFILIATION: Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA. shira.ninio@yale.edu

Country: England

AGENCY: United States NIAID

GRANT: AI41699

ACRONYM: AI

MEDLINETA: Trends Microbiol

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