Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model.

Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model. Research Abstract Details 

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Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model. Abstract Text:

Shinya Kohyama,Yuji Morimoto,Kanji Nakai,Tatsumi Kaji,Aya Tokumaru,Hiroshi Nawashiro,Katsuji Shima,Yasushi Satoh,Kunio Takishima,Makoto Kikuchi,Hirotaka Matsuo,Shinya Kohyama,Yuji Morimoto,Kanji Nakai,Tatsumi Kaji,Aya Tokumaru,Hiroshi Nawashiro,Katsuji Shima,Yasushi Satoh,Kunio Takishima,Makoto Kikuchi,Hirotaka Matsuo,

BACKGROUND AND OBJECTIVE: Narrow-band ultraviolet-B light (NBUVB) (313 nm) is known to have anti-proliferative effects, implying a potential treatment for intimal hyperplasia, but it remains to be ascertained. We assessed the effects of NBUVB irradiation for prevention of intimal hyperplasia. STUDY DESIGN/MATERIALS AND METHODS: The rat carotid arteries were irradiated with NBUVB after balloon injury (BI), and the degree of intimal hyperplasia was histopathologically assessed. The anti-proliferative effects using cultured human smooth muscle cells were evaluated by flow cytometry and immunoblot analysis. RESULTS: NBUVB (0.3-4.5 J/cm(2)) irradiation immediately after BI reduced the degree of intimal hyperplasia at 14 and 28 days after BI (P<0.001) without any obvious complications. Neither an increase in the number of medial cells nor upregulation of proliferating cell nuclear antigen was observed in the irradiated arteries. NBUVB irradiation at 2 or 14 days after BI significantly suppressed further intimal hyperplasia (P<0.01). NBUVB-irradiated cultured cells showed inhibited proliferation involved with G(1) and G(2)/M arrests. Increased expression of p53 and inhibition of retinoblastoma protein (pRB) phosphorylation were also seen in the NBUVB-irradiated cells. CONCLUSIONS: These data suggest that NBUVB irradiation is an effective method for preventing intimal hyperplasia. The anti-proliferative effect is partly due to the cell cycle arrest caused by p53 expression and inhibited pRB phosphorylation.

Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model. Publishing Authors By Initials

S Kohyama,Y Morimoto,K Nakai,T Kaji,A Tokumaru,H Nawashiro,K Shima,Y Satoh,K Takishima,M Kikuchi,H Matsuo,S Kohyama,Y Morimoto,K Nakai,T Kaji,A Tokumaru,H Nawashiro,K Shima,Y Satoh,K Takishima,M Kikuchi,H Matsuo,

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Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Lasers in surgery and medicine

VOLUME: 39

Page Numbers: 659-66

Journal Abbreviation:

ISSN: 0196-8092

DAY: 27

MONTH: Sep

YEAR: 2007

Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model. Information

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LANGUAGE: eng

NlmUniqueID: 8007168

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AFFILIATION: Department of Radiology, National Defense Medical College, Saitama, Japan 359-8513.

Country: United States

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MEDLINETA: Lasers Surg Med

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