[Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology]

[Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology] Research Abstract Details 

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[Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology] Abstract Text:

I I Derevianko,L A Nefedova,L N Lavrinova,

Complicated urinary infections tend to eventuate in severe pyoseptic complications--bacteriuria, sepsis. The search for methods of fighting agents of urinary infections goes in the direction of perfection of already existing methods and in the direction of design of novel antibacterial drugs. In the middle 1980s the first carbapenem drug-imipenem--was proposed for urological clinical practice. Mechanism of its action as that of the other beta-lactam antibiotics consists in impairment of synthesis of bacterial cell wall as a result of the drug penetration through the surface membrane and irreversible binding with penicillin-binding proteins. Imipenem is active against most gram-positive and gram-negative aerobic and anaerobic microorganisms which cause severe urological infections. The article presents the results of treatment of 45 patients with severe urological infections with multiple resistance of the causing agent and failure of previous treatment. Imipenem was given in a daily dose 1.5-2.0 g. Sometimes a stepwise regimen was used: 500 mg 4 times a day intravenously for the first 3-4 days, then 500 mg twice a day intramuscularly for the following 3-4 days. In detection of highly sensitive bacteria (E. coli, Proteus mirabilis) daily doses were reduced to 1 g. In long standing infection caused by Pseudomonas aeruginosa imipenem was combined with amicacin. In high surgical risk of postoperative period imipenem was given prior to surgery and continued after it for 5 to 14 days. Good therapeutic results were achieved: clinical effect reached 95.5%, antibacterial efficiency was 87.8%. Thus, imipenem is antibiotic of the first line in empirical therapy of severe bacterial infections in urology as it has a wide spectrum of antibacterial action. We believe that this drug should not be left as a reserve but used for a starting empirical therapy of severe infections in urological hospital.

[Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology] Publishing Authors By Initials

II Derevianko,LA Nefedova,LN Lavrinova,

For similar bacterial infections and mycoses: infection: urinary tract infections research abstracts see: bacterial infections and mycoses: infection: urinary tract infections research

PUBMED ID PMID:

MEDLINE DATE: 2002 May-Jun

[Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Urologii?a (Moscow, Russia : 1999)

VOLUME:

Page Numbers: 21-5

Journal Abbreviation:

ISSN: 1728-2985

DAY: 21

MONTH: 02

YEAR: 2008

[Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology] Information

Number of References:

LANGUAGE: rus

NlmUniqueID: 100900900

[Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology] Keywords Mesh Terms:

KEYWORDS: Urinary Tract Infections

MESH TERMS: microbiology

Chemical & Substance for Abstract: [Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology] Information

Substance Name: Cilastatin

Registry Number: 82009-34-5

Grant and Affiliation Information for [Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology]

AFFILIATION:

Country: Russia

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ACRONYM:

MEDLINETA: Urologiia

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