Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep.

Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep. Abstract Text:

G M Smith,J G Allen,

OBJECTIVE: To compare the effectiveness of combined selenium and alpha-tocopherol acetate treatments in preventing lupinosis-associated myopathy in sheep. DESIGN: Measurement of plasma muscle and liver enzymes, and histopathological examination of muscle and liver in the treatment groups. PROCEDURE: The treatments were: subcutaneous injections of selenomethionine and vitamin E (sc(SeM+E)), an intraruminal selenium pellet and oral doses of vitamin E and intramuscular injections of selenomethionine combined with either oral doses of vitamin E (imSeM+orE) or intramuscular injections of vitamin E in an oily carrier. Another group received no supplements, while a control group was given selenium pellets on day 0 and fortnightly oral doses of vitamin E from day 0 to 72. To produce lupinosis-associated myopathy, the sheep were fed a diet low in vitamin E and given repeated injections of a crude extract of Diaphorthe toxica. Groups sc(SeM+E) and imSeM+orE were stressed by dosing with protected polyunsaturated fatty acids from day 56 onwards. RESULTS: Lupinosis-associated myopathy was induced in all unsupplemented sheep. In these sheep the storage of Se increased and that of vitamin E decreased. The subcutaneous treatment was highly effective in preventing lupinosis-associated myopathy and also produced the highest vitamin E concentrations in plasma and liver. Supplemental vitamin E was more efficacious than supplemental Se. Concentrations of vitamin E in the livers of sheep given intramuscular vitamin E were higher than expected based on plasma concentrations. Oral doses of vitamin E proved the least effective method of increasing concentrations in liver. Lupinosis did not affect Se concentrations in liver or muscle. CONCLUSION: The sc(SeM+E) treatment is highly effective in preventing lupinosis-associated myopathy but needs to be further assessed when selenium and vitamin E are both limiting in the diet.

Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep. Publishing Authors By Initials

GM Smith,JG Allen,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

PUBMED ID PMID:

MEDLINE DATE:

Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Australian veterinary journal

VOLUME: 75

Page Numbers: 341-8

Journal Abbreviation: Aust. Vet. J.

ISSN: 0005-0423

DAY: 19

MONTH: May

YEAR: 1997

Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370616

Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep. Information

Substance Name: Selenium

Registry Number: 7782-49-2

Grant and Affiliation Information for Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep.

AFFILIATION: Animal Health Laboratories, Agriculture Western Australia, South Perth.

Country: AUSTRALIA

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Aust Vet J

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep Related Publications

• Access to adequate nutrition is a major potential obstacle to antiretroviral adherence among HIV-infected individuals in Rwanda.
• Axillary artery aneurysm with distal embolization in a major league baseball pitcher.
• Bupropion in the treatment of pathological gambling: a randomized, double-blind, placebo-controlled, flexible-dose study.
• Chapter 24: Psychosocial aspects of vaccine acceptability.
• Characterization of full-length hepatitis C virus genotype 4 sequences.
• Competence levels in musculoskeletal medicine: comparison of osteopathic and allopathic medical graduates.
• Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor.
• Disease emergence in multi-host epidemic models.
• Effectiveness of alpha-tocopherol and selenium supplements in preventing lupinosis-associated myopathy in sheep.
• Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning.
• Examination of the genital organs in the prepubescent and in the adolescent girl.
• Fluorometric evaluation of cryopreserved bovine spermatozoa extended in egg yolk and milk.
• Genital tract pressures in mares II. Changes induced by oxytocin and prostaglandin F(2)alpha.
• Indoor/Outdoor relationships, trends, and carbonaceous content of fine particulate matter in retirement homes of the Los Angeles Basin.
• Interview with Dr. Lee-Ann Allen regarding Pivotal Advance: Francisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escape. Interview by Helene F. Rosenberg.
• Letter to the editor.
• MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome.
• Nuclear pore clustering is a consistent feature of apoptosis in vitro.
• Phlorizin induces lipolysis and alters meal patterns in both early- and late-lactation dairy cows.
• Property grabbing and will writing in Lusaka, Zambia: an examination of wills of HIV-infected cohabiting couples.
• Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution.
• Recruitment of African American and white postmenopausal women into clinical trials: the beneficial effects of soy trial experience.
• Retrograde suppression of GABAergic currents in a subset of SCN neurons.
• Short communication: Rate of propionate infusion within meals does not influence feeding behavior.
• The effect of weight on intravaginal pressure and vulval conformation of mares.
• The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy.
• The use of catheter-tipped pressure transducers for chronic measurement of genital tract pressures in the ewe. II. Effects of oxytocin and prostaglandin F(2)alpha.
• Three dimensional MEMS microfluidic perfusion system for thick brain slice cultures.
• Two host-induced Ralstonia solanacearum genes, acrA and dinF, encode multidrug efflux pumps and contribute to bacterial wilt virulence.
• [Study on expression of adherent proteins related to regulation of hematopoiesis in long-term cultured human bone marrow stromal cells]