Effective microorganism fermentation extract (EM-X) attenuates airway hyperreactivity and inflammation through selective inhibition of the TH2 response independently of antioxidant activity.

Effective microorganism fermentation extract (EM-X) attenuates airway hyperreactivity and inflammation through selective inhibition of the TH2 response independently of antioxidant activity. Research Abstract Details 

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Effective microorganism fermentation extract (EM-X) attenuates airway hyperreactivity and inflammation through selective inhibition of the TH2 response independently of antioxidant activity. Abstract Text:

Jeong-Su Do,Hyo-Jung Seo,Jin-Ki Hwang,Jun-Hee Kim,Sang-Yun Nam,Jeong-Su Do,Hyo-Jung Seo,Jin-Ki Hwang,Jun-Hee Kim,Sang-Yun Nam,

The effective microorganism fermentation extract (EM-X) is an antioxidant cocktail derived from the fermentation of plant material with effective microorganisms, and its clinical application is being increasingly scrutinized. In the current study, the antiasthmatic effect of EM-X was investigated using a mouse model. Inhalation of EM-X during OVA challenge resulted in a significant reduction in airway hyperreactivity (AHR) and airway recruitment of leukocytes including eosinophils. However, the level of 8-isoprostane in bronchoalveolar lavage fluid (BALF), a marker of oxidative stress in asthmatic patients, was unaltered by EM-X inhalation. Instead, ELISA data showed that levels of IL-4, IL-5 and IL-13 in BALF or lung tissues were significantly lower in EM-X-inhaling mice than in the control mice, but not the IFN-gamma level. A considerably lower amount of Ag-specific IgE and IgG1 was detected in the serum of EM-X-inhaling mice than in the serum of the controls, whereas their IgG2a secretion was similar. In addition, Ag-specific ex vivo IL-4, IL-5 and IL-13 production of draining lymph node cells was markedly diminished by EM-X inhalation, but not IFN-gamma. These data clearly show that inhaled EM-X suppresses type 2 helper T (TH2), but not type 1 helper T (TH1), response. In conclusion, inhalation of EM-X attenuates AHR and airway inflammation which results from selective inhibition of the TH2 response to allergen, but independently of antioxidant activity. Our data also suggest that EM-X may be effectively applied for control of allergic asthma.

Effective microorganism fermentation extract (EM-X) attenuates airway hyperreactivity and inflammation through selective inhibition of the TH2 response independently of antioxidant activity. Publishing Authors By Initials

JS Do,HJ Seo,JK Hwang,JH Kim,SY Nam,JS Do,HJ Seo,JK Hwang,JH Kim,SY Nam,

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Effective microorganism fermentation extract (EM-X) attenuates airway hyperreactivity and inflammation through selective inhibition of the TH2 response independently of antioxidant activity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of molecular medicine

VOLUME: 20

Page Numbers: 631-5

Journal Abbreviation: Int. J. Mol. Med.

ISSN: 1107-3756

DAY: 5

MONTH: Oct

YEAR: 2007

Effective microorganism fermentation extract (EM-X) attenuates airway hyperreactivity and inflammation through selective inhibition of the TH2 response independently of antioxidant activity. Information

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LANGUAGE: eng

NlmUniqueID: 9810955

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Grant and Affiliation Information for Effective microorganism fermentation extract (EM-X) attenuates airway hyperreactivity and inflammation through selective inhibition of the TH2 response independently of antioxidant activity.

AFFILIATION: Department of Biological Science, Jeonju University, Jeonju 560-759, Korea.

Country: Greece

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MEDLINETA: Int J Mol Med

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