Effective bone engineering with periosteum-derived cells.

Effective bone engineering with periosteum-derived cells. Research Abstract Details 

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Effective bone engineering with periosteum-derived cells. Abstract Text:

H Agata,I Asahina,Y Yamazaki,M Uchida,Y Shinohara,M J Honda,H Kagami,M Ueda,

Bone augmentation via tissue engineering has generated significant interest. We hypothesized that periosteum-derived cells could be used in place of bone marrow stromal cells (which are widely used) in bone engineering, but the differences in osteogenic potential between these 2 cell types are unclear. Here, we compared the osteogenic potential of these cells, and investigated the optimal osteoinductive conditions for periosteum-derived cells. Both cell types were induced, via bFGF and BMP-2, to differentiate into osteoblasts. Periosteal cells proliferated faster than marrow stromal cells, and osteogenic markers indicated that bone marrow stromal cells were more osteogenic than periosteal cells. However, pre-treatment with bFGF made periosteal cells more sensitive to BMP-2 and more osteogenic. Transplants of periosteal cells treated with BMP-2 after pre-treatment with bFGF formed more new bone than did marrow stromal cells. Analysis of these data suggests that combined treatment with bFGF and BMP-2 can make periosteum a highly useful source of bone regeneration.

Effective bone engineering with periosteum-derived cells. Publishing Authors By Initials

H Agata,I Asahina,Y Yamazaki,M Uchida,Y Shinohara,MJ Honda,H Kagami,M Ueda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Effective bone engineering with periosteum-derived cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of dental research

VOLUME: 86

Page Numbers: 79-83

Journal Abbreviation: J. Dent. Res.

ISSN: 0022-0345

DAY: 19

MONTH: Jan

YEAR: 2007

Effective bone engineering with periosteum-derived cells. Information

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LANGUAGE: eng

NlmUniqueID: 354343

Effective bone engineering with periosteum-derived cells. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effective bone engineering with periosteum-derived cells. Information

Substance Name: Alkaline Phosphatase

Registry Number: EC 3.1.3.1

Grant and Affiliation Information for Effective bone engineering with periosteum-derived cells.

AFFILIATION: Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Country: United States

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MEDLINETA: J Dent Res

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