Effect of zinc on the immune status of zinc-depleted AIDS related complex patients.

Effect of zinc on the immune status of zinc-depleted AIDS related complex patients. Research Abstract Details 

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Effect of zinc on the immune status of zinc-depleted AIDS related complex patients. Abstract Text:

J F Zazzo,B Rouveix,P Rajagopalon,M Levacher,P M Girard,

Zinc deficiency has been recently reported in AIDS patients to be associated with a decrease in T helper cells. The effect of zinc supplementation was evaluated in 5 ARC patients and 5 control subjects using lymphocyte subset counts, blast transformation and chemiluminescence of polymorphonuclear leukocytes. Zinc was analysed by atomic absorption spectrophotometry. T-cell subsets were quantified by cytofluorometry. Chemiluminescence of PMN was measured by phagocytosis of opsonized zymosan. The ARC patients had significantly lower zinc concentrations in the RBC prior to supplementation (p < 0.05). This level increased following the administration of zinc gluconate. This increase was accompanied by (i) an increase in HLA.Dr + cells with no CD4 CD8 ratio alteration; (ii) a stimulation of lymphocyte transformation and PMN chemiluminescence particularly after 15 days' high zinc supplementation. Such a reconstitution in specific and non specific immune functions in ARC patients may warrant further investigation.

Effect of zinc on the immune status of zinc-depleted AIDS related complex patients. Publishing Authors By Initials

JF Zazzo,B Rouveix,P Rajagopalon,M Levacher,PM Girard,

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Effect of zinc on the immune status of zinc-depleted AIDS related complex patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nutrition (Edinburgh, Scotland)

VOLUME: 8

Page Numbers: 259-61

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ISSN: 0261-5614

DAY: 13

MONTH: Oct

YEAR: 1989

Effect of zinc on the immune status of zinc-depleted AIDS related complex patients. Information

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LANGUAGE: eng

NlmUniqueID: 8309603

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Grant and Affiliation Information for Effect of zinc on the immune status of zinc-depleted AIDS related complex patients.

AFFILIATION: Département d'Anesthésiologie, Hôpital Antoine Béclère, 92140, Clamart, France.

Country: England

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MEDLINETA: Clin Nutr

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