Effect of voluntary weight loss on bone mineral density in older overweight women.

Effect of voluntary weight loss on bone mineral density in older overweight women. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of voluntary weight loss on bone mineral density in older overweight women. Abstract Text:

OBJECTIVES: To examine the effect of diet and exercise-induced weight loss on bone mineral density in overweight postmenopausal women DESIGN: A 1-year prospective, randomized clinical trial. SETTING: Two university medical school research centers. PARTICIPANTS: Sixty-seven overweight postmenopausal women, a subset of the women who participated in the Trial of Nonpharmacological Interventions in the Elderly (TONE) to control hypertension. The participants were assigned randomly to one of four groups: usual care, weight loss only, sodium restriction only, or combined weight loss/sodium restriction. INTERVENTION: All TONE participants in the treatment groups attended regular dietary intervention sessions to lose weight, reduce sodium intake, or both that they might refrain from using antihypertensive medications for a period of 15 to 36 months (median = 29 months). MEASUREMENTS: Bone mineral density (BMD) assessed by dual energy X-ray absorptiometry (DXA), serum and urine markers of bone metabolism, and other demographic and clinical data were collected at baseline, 6 months, and 12 months. RESULTS: Women assigned to the weight loss interventions lost 9.2 +/- 1.2 lbs (mean +/- SE) at 6 months and 7.7 +/- 2.0 lbs at 12 months compared with 1.8 +/- 1.0 lbs at 6 months and 1.9 +/- 1.6 lbs at 12 months for those assigned to no weight loss intervention (P < .0001). Weight loss was correlated with a decrease in total body BMD (P = .004) and an increase in osteocalcin (P = .004) after controlling for baseline bone measures, intervention assignment, and other baseline covariates. Regression analyses indicated that total body BMD decreased by 6.25 +/- 2.06 g/cm2 x 10-4 for each pound of weight loss. CONCLUSIONS: Voluntary weight loss in overweight postmenopausal women is associated with modest decrease in total body BMD. Clinicians recommending weight loss for older postmenopausal women may need to include recommendations for reducing the risk of bone loss.

Effect of voluntary weight loss on bone mineral density in older overweight women. Publishing Authors By Initials

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research

PUBMED ID PMID:

MEDLINE DATE:

Effect of voluntary weight loss on bone mineral density in older overweight women. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Geriatrics Society

VOLUME: 48

Page Numbers: 753-9

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Jul

YEAR: 2000

Effect of voluntary weight loss on bone mineral density in older overweight women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503062

Effect of voluntary weight loss on bone mineral density in older overweight women. Keywords Mesh Terms:

KEYWORDS: Weight Loss

MESH TERMS: physiology

Chemical & Substance for Abstract: Effect of voluntary weight loss on bone mineral density in older overweight women. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of voluntary weight loss on bone mineral density in older overweight women.

AFFILIATION: Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: R01 HL-48642

ACRONYM: HL

MEDLINETA: J Am Geriatr Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of voluntary weight loss on bone mineral density in older overweight women Related Publications

• "To treat or not to treat--that is an important question".
• A personal perspective on fracture risk assessment tools.
• A time of change.
• Appropriate intervention through fracture risk assessment.
• Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia.
• Correction of B.O.D. velocity constants for nitrification.
• Effect of voluntary weight loss on bone mineral density in older overweight women.
• Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration.
• Gemcitabine plus radiation therapy in the treatment of locally advanced non small-cell lung cancer.
• Inherited ADAMTS13 deficiency: unique presentation and treatment.
• Laser safety program. LA-3731-MS.
• Long-term exercise and its effect on balance in older, osteoarthritic adults: results from the Fitness, Arthritis, and Seniors Trial (FAST).
• Lucigenin chemiluminesence. A new approach to study the redox activity of Ehrlich ascetic tumor cells.
• Mapping the functional anatomy of sentence comprehension and application to presurgical evaluation of patients with brain tumor.
• Persistence with weekly alendronate therapy among postmenopausal women.
• Physical activity and older people: a walk a day keeps the doctor away.
• Physical activity, functional limitations, and disability in older adults.
• Public health issues in geriatric dentistry in the United States.
• Radioactive iron absorption in siderosis (hemochromatosis) of the liver.
• Response to "inherited ADAMTS13 deficiency: unique presentation and treatment".
• Rural dentistry--lessons from other countries.
• Small intestinal pattern in sprue and similar deficiency diseases.
• Survey of techniques employed to define aerosol "respirable dust" concentration and particle size characteristics. LA-4249.
• The Balanced Budget Act of 1997: implications for the practice of geriatric medicine.
• The war on health care fraud and abuse: peril for providers.
• Unusual EEG in coma after cardiac arrest.
• [Mental diseases of old age]
• [Role of the autonomic nervous system in regulating the parietal pH of the digestive tract in rats]
• [The effect of natural and synthetic antioxidants on the profile of the parietal pH of the digestive tract in rats under normal and pathologic conditions]
• [The role of the parasympathetic nervous system in regulating the oxygen tension and regional blood flow in the digestive organs of rats]