Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes.

Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Abstract Text:

R K Li,D B Cowan,D A Mickle,R D Weisel,G W Burton,

To determine the effect of vitamin E on cellular antioxidant enzymes, human ventricular cardiomyocytes were incubated with 200 microM all-racemic-alpha-tocopheryl acetate for 14 d at pO2s of 150 and 40 mm Hg. Cellular Cu, Zn superoxide dismutase, catalase, and GSH-Px1 activities were measured. Although SOD and catalase activities were unaffected by alpha-tocopherol, GSH-Px1 activities increased (p < .0001) as much as twofold. This increase was independent of oxygen tension and selenium. The increase in GSH-Px1 activity became significant (p < .01) by day 4. A nonantioxidant analog of alpha-tocopherol, 200 microM RRR-alpha-tocopherol methyl ether, did not affect GSH-Px1 activities. Although GSH-Px1 mRNA levels mirrored the changes in enzyme activities, the de novo nuclear GSH-Px1 transcript synthesis was unaffected by alpha-tocopherol. Because the increase in GSH-Px1 activities also occurred after cellular alpha-tocopherol levels had plateaued, the above results were most consistent with posttranscriptional stabilization of GSH-Px1 mRNA by alpha-tocopherol or an alpha-tocopherol-related metabolic product.

Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Publishing Authors By Initials

RK Li,DB Cowan,DA Mickle,RD Weisel,GW Burton,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

PUBMED ID PMID:

MEDLINE DATE:

Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Free radical biology & medicine

VOLUME: 21

Page Numbers: 419-26

Journal Abbreviation: Free Radic. Biol. Med.

ISSN: 0891-5849

DAY: 19

MONTH: 11

YEAR: 1996

Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8709159

Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Information

Substance Name: Superoxide Dismutase

Registry Number: EC 1.15.1.1

Grant and Affiliation Information for Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes.

AFFILIATION: Department of Clinical Biochemistry, Toronto Hospital, Ontario, Canada.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Free Radic Biol Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of vitamin E on human glutathione peroxidase GSH-PX1 expression in cardiomyocytes Related Publications

• A novel thermostable nitrilase superfamily amidase from Geobacillus pallidus showing acyl transfer activity.
• Adolescent idiopathic scoliosis: natural history and long term treatment effects.
• Aminopterin might be safe in ALL.
• Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis.
• Antibodies to West Nile virus: a double-edged sword.
• Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy.
• Biokinetics in humans of RRR-alpha-tocopherol: the free phenol, acetate ester, and succinate ester forms of vitamin E.
• Booklet-based education in vestibular rehabilitation or symptom control improved subjective health in Ménière disease.
• Diabetes expert accuses drug company of "intimidation".
• Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors.
• Does poor housing raise diabetes risk?
• Early African Diaspora in colonial Campeche, Mexico: strontium isotopic evidence.
• Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes.
• Effects of masking noise on vowel and sibilant contrasts in normal-hearing speakers and postlingually deafened cochlear implant users.
• Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene.
• HIV-1 neutralization: mechanisms and relevance to vaccine design.
• Hits and false positives in face matching: a familiarity-based dissociation.
• Isonychia spp. and macroinvertebrate community responses to stressors in streams utilizing the benthic in situ toxicity identification evaluation (BiTIE) method.
• Metabolic cardiomyopathy and mitochondrial disorders in the pediatric intensive care unit.
• Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit.
• Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.
• Primary intracranial leiomyosarcoma: report of a case and review of the literature.
• Smokers' interest in using nicotine replacement to aid smoking reduction.
• Symptom domains of schizophrenia: the role of atypical antipsychotic agents.
• The Benefits of using MRI-CT Fused Images for Post-implant Prostate Dosimetry.
• Time course of speech changes in response to unanticipated short-term changes in hearing state.
• Use and approximation of the air mixing factor used in dilution ventilation in industrial settings.
• Validity of polygraphs.
• What's new in azithromyin?
• Withanolides from Jaborosa laciniata.