Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats.

Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats. Research Abstract Details 

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Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats. Abstract Text:

T Yoshikawa,Y Furukawa,M Murakami,K Watanabe,M Kondo,

Experimental disseminated intravascular coagulation (DIC) can be induced by 4 hr sustained infusion of endotoxin in a dose of 100 mg/kg in rats. The experimental model of DIC in rats was used to study the preventive effect of vitamin E, alpha-tocopheryl acetate, against DIC. Before the infusion of endotoxin, 0.01, 0.1, 1.0 or 10.0 mg/kg/day of alpha-tocopheryl acetate was injected intraperitoneally for 4 successive days. The preventive effect against DIC was noted in all the parameters, such as fibrinogen and fibrin degradation products, fibrinogen level, prothrombin time, partial thromboplastin time, platelet count, and the number of renal glomeruli with fibrin thrombi, in rats treated with 1.0 or 10.0 mg/kg of alpha-tocopheryl acetate. From these results, it was shown that vitamin E, alpha-tocopheryl acetate, inhibited endotoxin-induced experimental DIC in rats.

Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats. Publishing Authors By Initials

T Yoshikawa,Y Furukawa,M Murakami,K Watanabe,M Kondo,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Thrombosis and haemostasis

VOLUME: 48

Page Numbers: 235-7

Journal Abbreviation: Thromb. Haemost.

ISSN: 0340-6245

DAY: 29

MONTH: Oct

YEAR: 1982

Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats. Information

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LANGUAGE: eng

NlmUniqueID: 7608063

Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats. Information

Substance Name: Fibrinogen

Registry Number: 9001-32-5

Grant and Affiliation Information for Effect of vitamin E on endotoxin-induced disseminated intravascular coagulation in rats.

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Country: GERMANY, WEST

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MEDLINETA: Thromb Haemost

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