Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage.

Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. Research Abstract Details 

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Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. Abstract Text:

T Yasunaga,H Kato,K Ohgaki,T Inamoto,Y Hikasa,

Studies have been done to determine the optimal dosage of vitamin E. Vitamin E is generally considered to be relatively nontoxic at high dosage in spite of the fact that it is a fat-soluble vitamin. From our experiments using mice, when various dosages of all-rac-alpha-tocopherol were injected into the intraperitoneal cavity every day, 1) the body weight decreased when the dose was more than 100 IU/kg per day, and all the mice died within 3 days at 400 IU/kg per day; 2) immune responses investigated by lymphoproliferative assays with phytohemagglutinin, concanavalin A and lipopolysaccharide were enhanced significantly between 5 and 20 IU/kg per day, but were inhibited by 80 IU/kg per day. When the immunopotentiation effect of vitamin E was discernible, serum tocopherol levels were about twice the control values. From our results, the optimal dosage of vitamin E was between 5 and 20 IU/kg per day, and dosages over 80 IU/kg per day were toxic to mice. We then experimented similarly with vitamin K, which is fat soluble and possesses a quinone structure resembling vitamin E. When doses between 12.5 and 150 mg/kg per day of vitamin K were injected into the intraperitoneal cavity daily fore 14 days, increase of body weight was generally inhibited. This did not depend on the dose, and there was no definite relationship between mitogen responses and vitamin K.

Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. Publishing Authors By Initials

T Yasunaga,H Kato,K Ohgaki,T Inamoto,Y Hikasa,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of nutrition

VOLUME: 112

Page Numbers: 1075-84

Journal Abbreviation: J. Nutr.

ISSN: 0022-3166

DAY: 19

MONTH: Jun

YEAR: 1982

Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. Information

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LANGUAGE: eng

NlmUniqueID: 404243

Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. Information

Substance Name: tocopherol acetate

Registry Number: 7695-91-2

Grant and Affiliation Information for Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage.

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Country: UNITED STATES

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MEDLINETA: J Nutr

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