Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats.

Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats. Research Abstract Details 

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Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats. Abstract Text:

Dan Wei,Ming Li,Wenjun Ding,Dan Wei,Ming Li,Wenjun Ding,

An insulin signaling pathway microarray was used to evaluate the gene expression profiling of the insulin signaling pathway in the skeletal muscle of streptozotocin-induced diabetic, NaVO(3)-treated diabetic and insulin-treated diabetic rats for the investigation of the effect of vanadium and insulin on the insulin signaling pathway. Of 96 genes surveyed, transcriptional patterns of 19 genes (20%) showed alterations in diabetic rats compared with controls. Although most of these changed gene expressions were improved after treatment with NaVO(3) (14, 74%) and insulin (16, 84%), NaVO(3) and insulin treatment resulted in the alteration of 20 and 12 additional gene transcripts compared no treatment. We found that both NaVO(3) and insulin treatment achieved a desirable glucose level and most of the alterative gene transcripts in diabetic rats were normalized with NaVO(3) and insulin treatment. Comparison of the gene expression profiling indicates that there is a significant difference between the NaVO(3)-treated group and the insulin-treated group. The present study demonstrated for the first time that several candidate genes of the insulin signaling pathway are involved in the effect of vanadium treatment on hyperglycemia. This study opens the way for more focused investigations that may identify the genes responsible for diabetes and vanadium treatment in the global insulin signaling pathway.

Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats. Publishing Authors By Initials

D Wei,M Li,W Ding,D Wei,M Li,W Ding,

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Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biological inorganic chemistry : JBIC :

VOLUME: 12

Page Numbers: 1265-73

Journal Abbreviation: J. Biol. Inorg. Chem.

ISSN: 0949-8257

DAY: 14

MONTH: 09

YEAR: 2007

Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats.

AFFILIATION: Department of Biology, Graduate University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, People's Republic of China.

Country: Germany

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MEDLINETA: J Biol Inorg Chem

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