Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects.

Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects. Abstract Text:

Je Gern,Ck Stone,M Nakano,Db Muchmore,A ,S Park,A Suri,F Tibaldi,D Soon,Ww Busse,J E Gern,C K Stone,M Nakano,D B Muchmore,A de la Peña,S Park,A Suri,F Tibaldi,D Soon,W W Busse,J E Gern,C K Stone,M Nakano,D B Muchmore,A de la Peña,S Park,A Suri,F Tibaldi,D Soon,W W Busse,

The suitability of employing AIR Inhaled Insulin (AIR Insulin; AIR is a registered trademark of Alkermes) during acute upper respiratory tract infection (URI) has not been determined. Twenty-one healthy, non-diabetic subjects were enrolled in a single-sequence, two-period, euglycemic clamp study. Subjects received a single 12 U-equivalent dose of AIR Insulin before rhinovirus (RV16) inoculation and during symptomatic infection. Spirometry was used to evaluate pulmonary safety. AIR Insulin exposure (the area under the immunoreactive insulin (IRI) concentration vs time curve from time zero until the IRI concentrations returned to the predose baseline value (AUC(0-t'))) and glucodynamic response (total amount of glucose infused (G(tot))) were comparable before and during RV infection (AUC(0-t') 46,300 vs 52,600 pmol min/l, P=0.21; G(tot) 61,800 vs 68,700 mg, P=0.42, respectively). Variability of pharmacokinetic and pharmacodynamic parameters did not change during URI; either did the number or intensity of adverse events. No significant change in forced expiratory volume or forced vital capacity was observed following AIR Insulin administration or during URI. The AIR Insulin system provides similar pharmacokinetic and glucodynamic responses under conditions of an experimentally induced RV infection and is regarded as suitable for use in diabetic patients during URIs.Clinical Pharmacology & Therapeutics (2008) doi:10.1038/sj.clpt.6100286.

Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects. Publishing Authors By Initials

J Gern,C Stone,M Nakano,D Muchmore,A ,S Park,A Suri,F Tibaldi,D Soon,W Busse,JE Gern,CK Stone,M Nakano,DB Muchmore,A de la Peña,S Park,A Suri,F Tibaldi,D Soon,WW Busse,JE Gern,CK Stone,M Nakano,DB Muchmore,A de la Peña,S Park,A Suri,F Tibaldi,D Soon,WW Busse,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 83

Page Numbers: 307-11

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 11

MONTH: 07

YEAR: 2007

Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890581

Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects.

AFFILIATION: 1Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects Related Publications

• Age-related changes in eosinophil function in human subjects.
• Analysis of differences in proportions from clustered data with multiple measurements in diagnostic studies.
• Arabic acid and its salts. II. The effect of cations on the viscosity of arabic acid solutions.
• Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects.
• Elective aortocoronary bypass grafting in the elderly.
• Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells.
• From low to high: late-onset intracranial hypertension after treatment of spontaneous intracranial hypotension.
• Hypochondriasis in the elderly: a reaction to social stress.
• Influence of electrolytes, pH, and alcohol concentration on the solubilities of acidic drugs.
• Ligation of intercellular adhesion molecule 3 induces apoptosis of human blood eosinophils and neutrophils.
• Long term oscillation in glycolysis.
• Mechanism of action of nafazatrom.
• Modernization of the medical Sherlock Holmes.
• Navigation concepts for MR image-guided interventions.
• New patterns of centrifugally driven thermal convection.
• Ochrobactrum haematophilum sp. nov. and Ochrobactrum pseudogrignonense sp. nov., isolated from human clinical specimens.
• One medical school's approach to teaching problems of the aging.
• Physical problems of psychiatrically hospitalized elderly persons.
• Pricing behaviour of pharmacies after market deregulation for OTC drugs: the case of Germany.
• Proposal of Viridibacillus gen. nov. and reclassification of Bacillus arvi, Bacillus arenosi and Bacillus neidei as Viridibacillus arvi gen. nov., comb. nov., Viridibacillus arenosi comb. nov. and Viridibacillus neidei comb. nov.
• Reclassification of Pseudomonas mephitica Claydon and Hammer 1939 as a later heterotypic synonym of Janthinobacterium lividum (Eisenberg 1891) De Ley et al. 1978.
• Reorientation of a hexagonal pattern under broken symmetry: the hexagon flip.
• Right ventricular wall hematoma due to thrombolytic therapy presenting as cardiac tamponade: a case report and review of literature.
• Sudden improvement of insulin sensitivity related to an endodontic treatment.
• The modern challenge of threescore and ten.
• Three-dimensional imaging using a frequency-domain synthetic aperture focusing technique.
• [Accident mechanisms and classification in distal radius fracture]
• [Aerosol disinfection of airborne bacteria-investigations with the microthread technique (author's transl)]
• [The value of postoperative antibiotic prophylaxis following abdominal and vaginal hysterectomy]
• [Tumours of the lacrimal passages.]