Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo.

Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Research Abstract Details 

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Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Abstract Text:

G N King,N King,F J Hughes,

Resorbable collagen membranes for guided tissue regeneration in periodontal therapy have shown promise but are not osteoinductive. As recombinant human bone morphogenetic protein-2 (rhBMP-2) is known to have an affinity for collagen, the use of this osteoinductive agent incorporated into a collagen vehicle may act as a suitable carrier to promote periodontal regeneration. The aim of this study was to investigate the effects of two different collagen delivery systems for rhBMP-2 in rat periodontal fenestration defects. Using the collagen membrane delivery system, 3 groups of adult Wistar rats which had surgical defects created on the right side of the mandible involving the removal of bone and exposure of the molar roots were treated with either rhBMP-2 in colagen membrane (BMPm) (n = 12 animals), or collagen membrane only (COLm) (n = 12), or were left untreated (UN) (n = 14). Using the collagen gel delivery system, surgical defects were treated with either rhBMP-2 incorporated in a collagen gel carrier (BMPg) (n = 5) or had collagen gel only (COLg) (n = 6). Animals were killed 10 d postoperatively and tissues processed for histology. New bone formation was significantly greater in BMPg compared with both BMPm and controls (p < 0.05). However, new cementum formation was significantly greater in BMPm (721 +/- 166 micron2, mean +/- SE) compared with COLm, COLg and UN (p < 0.02) (190 +/- 44 micron2, 327 +/- 114 micron2 and 172 +/- 33 micron2, respectively) and more than 1.5 times BMPg (451 +/- 158 micron2). In conclusion, both carrier systems for rhBMP-2 significantly increased new bone formation compared with controls during the early stages of periodontal wound healing. However, the more slowly dissolving collagen membrane carrier system for rhBMP-2 produced significantly greater new cementum compared with the collagen gel carrier, suggesting that a more prolonged exposure of rhBMP-2 is required to increased cementogenesis.

Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Publishing Authors By Initials

GN King,N King,FJ Hughes,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of periodontal research

VOLUME: 33

Page Numbers: 226-36

Journal Abbreviation: J. Periodont. Res.

ISSN: 0022-3484

DAY: 19

MONTH: May

YEAR: 1998

Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 55107

Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo.

AFFILIATION: Department of Periodontology, St Bartholomew's & The Royal London School of Medicine and Dentistry, University of London, UK.

Country: DENMARK

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MEDLINETA: J Periodontal Res

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