Effect of topical vitamin D analogue on in vivo contact sensitization.

Effect of topical vitamin D analogue on in vivo contact sensitization. Research Abstract Details 

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Effect of topical vitamin D analogue on in vivo contact sensitization. Abstract Text:

Kaija K Hanneman,Heather M Scull,Kevin D Cooper,Elma D Baron,

BACKGROUND: The immunomodulatory role of vitamin D and its analogues has been demonstrated in vitro and in vivo using animal models. We evaluated the effect of a vitamin D analogue, calcipotriene, in vivo on human subjects using a contact hypersensitivity model. OBSERVATIONS: Subjects were pretreated with topical calcipotriene, simulated solar radiation, or both on buttock skin. They were then sensitized and challenged using the contact allergen dinitrochlorobenzene. Immune response was measured by change in skinfold thickness before vs after elicitation across the challenge sites. CONCLUSIONS: Calcipotriene-treated individuals demonstrated 64% immunosuppression compared with untreated controls. This is equivalent to the immunosuppression induced by UV exposure.

Effect of topical vitamin D analogue on in vivo contact sensitization. Publishing Authors By Initials

KK Hanneman,HM Scull,KD Cooper,ED Baron,

For similar environment and public health: environment: meteorological factors: atmosphere: weather: sunlight research abstracts see: environment and public health: environment: meteorological factors: atmosphere: weather: sunlight research

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Effect of topical vitamin D analogue on in vivo contact sensitization. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of dermatology

VOLUME: 142

Page Numbers: 1332-4

Journal Abbreviation:

ISSN: 0003-987X

DAY: 3

MONTH: Oct

YEAR: 2006

Effect of topical vitamin D analogue on in vivo contact sensitization. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Effect of topical vitamin D analogue on in vivo contact sensitization. Keywords Mesh Terms:

KEYWORDS: Sunlight

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effect of topical vitamin D analogue on in vivo contact sensitization. Information

Substance Name: Dinitrochlorobenzene

Registry Number: 97-00-7

Grant and Affiliation Information for Effect of topical vitamin D analogue on in vivo contact sensitization.

AFFILIATION: Department of Dermatology, Skin Study Center, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, Ohio 44106, USA. kaija.hanneman@uhhs.com

Country: United States

AGENCY: United States NIAMS

GRANT: AR39750

ACRONYM: AR

MEDLINETA: Arch Dermatol

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