Effect of topical mitomycin C on corneal endothelium.

Effect of topical mitomycin C on corneal endothelium. Research Abstract Details 

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Effect of topical mitomycin C on corneal endothelium. Abstract Text:

Anita Panda,Jacob Pe'er,Anand Aggarwal,Hrishikesh Das,Abhiyan Kumar,Shalini Mohan,

PURPOSE: To evaluate patients with ocular surface squamous neoplasia (OSSN) on treatment with topical mitomycin C (MMC) with regard to changes in corneal thickness and endothelial count. DESIGN: Prospective, nonrandomized, interventional series. METHODS: In this prospective evaluation, 25 patients with OSSN with different clock hours of involvement (range, one to eight), age varying from 19 to 76 years, were treated with topical MMC 0.04% in a cyclic manner. Preoperative corneal thickness measurement and endothelial cell density were obtained, and the tests were repeated after one, three, and six months of complete resolution. The fellow eyes of the same patients served as controls. RESULTS: Mean +/- standard deviation (SD) pachymetry and endothelial cell counts before and after instillation were 504.48 +/- 5.45 mum and 2325.76 +/- 192.52 cells/mm(2) and 503.52 +/- 5.75 mum and 2297.60 +/- 192.08 cells/mm(2), respectively, suggesting no significant difference in the above two parameters. Similarly, in the fellow control eyes, mean +/- SD pachymetry and endothelial cell counts before and after instillation were 502.80 +/- 4.34 mum and 2326.72 +/- 191.93 cells/mm(2) and 504.64 +/- 5.19 mum and 2313.60 +/- 192.03 cells/mm(2), respectively. CONCLUSIONS: Topical 0.04% MMC drops do not significantly affect the corneal endothelium. However, its judicious use and long-term follow-up are mandatory.

Effect of topical mitomycin C on corneal endothelium. Publishing Authors By Initials

A Panda,J Pe'er,A Aggarwal,H Das,A Kumar,S Mohan,

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Effect of topical mitomycin C on corneal endothelium. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of ophthalmology

VOLUME: 145

Page Numbers: 635-638

Journal Abbreviation: Am. J. Ophthalmol.

ISSN: 0002-9394

DAY: 1

MONTH: 02

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Cornea, Ocular Surface Disease, and Refractive Surgery Services, Dr R P Centre, All India Institute of Medical Sciences, New Delhi, India.

Country: United States

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MEDLINETA: Am J Ophthalmol

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