Effect of the Plant Product Croton Oil on the in vivo Incorporation of 3H-Thymidine. Evidence for a Pronounced Inhibition in the Thymus.

Effect of the Plant Product Croton Oil on the in vivo Incorporation of 3H-Thymidine. Evidence for a Pronounced Inhibition in the Thymus. Research Abstract Details 

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Effect of the Plant Product Croton Oil on the in vivo Incorporation of 3H-Thymidine. Evidence for a Pronounced Inhibition in the Thymus. Abstract Text:

B Hellmann,

An IN VIVO technique for screening interference with the DNA synthesis was used for evaluating the effects of croton oil (the oil from the seeds of CROTON TIGLIUM). The effect on the DNA turnover in various organs of the mouse was studied by measuring the incorporation of [6- (3)H]-thymidine. Twenty-four hours after an intraperitoneal injection, croton oil (2 mg/kg) significantly reduced the uptake of (3)H-thymidine into the thymus, spleen, liver, and small intestine. The most potent effect was observed in the thymus, the incorporated amount of (3)H-thymidine corresponding to 11% of that found in the controls. The inhibitory effects of croton oil were transitory and no longer present three days after the injection. Croton oil is usually regarded as a tumour promoter, not being carcinogenic PER SE. It is therefore of interest to note that the active principle of croton oil (12- O-tetradecanoyl-phorbol-13-acetate, TPA) has been reported to induce skin tumours in mice. If this effect of TPA can be confirmed, it will support the idea that the present observation of a marked inhibition of the (3)H-thymidine incorporation may reflect genotoxic properties of croton oil.

Effect of the Plant Product Croton Oil on the in vivo Incorporation of 3H-Thymidine. Evidence for a Pronounced Inhibition in the Thymus. Publishing Authors By Initials

B Hellmann,

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Effect of the Plant Product Croton Oil on the in vivo Incorporation of 3H-Thymidine. Evidence for a Pronounced Inhibition in the Thymus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Planta medica

VOLUME: 52

Page Numbers: 294-6

Journal Abbreviation: Planta Med.

ISSN: 0032-0943

DAY: 8

MONTH: Aug

YEAR: 1986

Effect of the Plant Product Croton Oil on the in vivo Incorporation of 3H-Thymidine. Evidence for a Pronounced Inhibition in the Thymus. Information

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LANGUAGE: eng

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AFFILIATION: Department of Toxicology, Uppsala University, Uppsala Biomedical Center, Box 594, S-75124 Uppsala, Sweden.

Country: Germany

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MEDLINETA: Planta Med

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