Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression.

Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression. Research Abstract Details 

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Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression. Abstract Text:

Aye Mu Myint,Harry W M Steinbusch,Liam Goeghegan,Dirk Luchtman,Yong Ku Kim,Brian E Leonard,Aye Mu Myint,Harry W M Steinbusch,Liam Goeghegan,Dirk Luchtman,Yong Ku Kim,Brian E Leonard,

BACKGROUND: The olfactory bulbectomised (OBX) rat model is a chronic model of depression in which behavioural and neuroimmunoendocrine changes are reversed only after chronic antidepressant treatment. The cyclooxygenase 2 (COX-2) inhibitor celecoxib has been shown to improve the depressive symptoms in patients with major depression. METHODS: The association between blood and brain immunological and behavioural changes in chronic treatment with COX-2 inhibitor was explored in the OBX rats and their sham-operated controls. RESULTS: The OBX group showed significantly higher locomotor activity than the other groups in the first 5 min in the open field. In the home cage emergence test, the OBX group showed a significantly shorter latency period compared to the sham group (z = -3.192, p = 0.001) but there was no difference between the other three groups. In the hypothalamus, the OBX group had a significantly higher interleukin 1beta (IL-1beta) concentration than the OBX + celecoxib group (z = -1.89, p = 0.05) as well as a significantly higher IL-10 concentration (z = -1.995, p = 0.046). In the prefrontal cortex, the OBX group showed significantly higher concentrations of tumour necrosis factor alpha (z = -2.205, p = 0.028) and IL-1beta (z = -3.361, p = 0.001) than the OBX + celecoxib group, but a significantly lower concentration of IL-10 (p = -3.361, p = 0.001) than the OBX + celecoxib group. CONCLUSIONS: The results of this study supported the potential therapeutic role of the COX-2 inhibitor celecoxib. It is possible that the behavioural changes following the chronic administration of celecoxib to the OBX rats are associated with an attenuation of the increase in the pro-inflammatory cytokines in the brain.

Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression. Publishing Authors By Initials

AM Myint,HW Steinbusch,L Goeghegan,D Luchtman,YK Kim,BE Leonard,AM Myint,HW Steinbusch,L Goeghegan,D Luchtman,YK Kim,BE Leonard,

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Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroimmunomodulation

VOLUME: 14

Page Numbers: 65-71

Journal Abbreviation: Neuroimmunomodulation

ISSN: 1021-7401

DAY: 21

MONTH: 08

YEAR: 2007

Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression. Information

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LANGUAGE: eng

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AFFILIATION: Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands.

Country: Switzerland

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MEDLINETA: Neuroimmunomodulation

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