Effect of surfactant on the characteristics of biodegradable microcapsules.

Effect of surfactant on the characteristics of biodegradable microcapsules. Research Abstract Details 

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Effect of surfactant on the characteristics of biodegradable microcapsules. Abstract Text:

Richard A Graves,Raisa Moiseyev,Thomas Freeman,Tarun K Mandal,

The objective of this project was to evaluate the effect of several lipophilic surfactants on the characteristics of PLGA microcapsules. BSA was used as a model peptide. Seven different lipophilic surfactants were used and each of the surfactants was used at three different concentrations, 0.1, 0.5 and 1% (w/w), respectively. The microcapsules were prepared using the double emulsion solvent evaporation technique. The microcapsules were all spherical in shape with a smooth surface. The median size of the microcapsules varied between 4 and 49 microm. The zeta potential of the microcapsules varied between -26 and -43 mV. The efficiency of encapsulation varied between 8 and 45%. Efficiency of encapsulation appears to be dependant on both the type and concentration of the surfactant. Cumulative percent of BSA released up to 35 days varied from 18 to 78%. In conclusion, the physical characteristics of the microcapsules do not appear to be greatly affected by the type of surfactant. All of the samples appear to show polydispersity in their particle sizes. Particle charge depended on both the type and concentration of the surfactant. The overall dissolution of these microcapsules was very slow.

Effect of surfactant on the characteristics of biodegradable microcapsules. Publishing Authors By Initials

RA Graves,R Moiseyev,T Freeman,TK Mandal,

For similar chemical actions and uses: specialty uses of chemicals: surface-active agents research abstracts see: chemical actions and uses: specialty uses of chemicals: surface-active agents research

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Effect of surfactant on the characteristics of biodegradable microcapsules. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 16

Page Numbers: 585-96

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2005

Effect of surfactant on the characteristics of biodegradable microcapsules. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Effect of surfactant on the characteristics of biodegradable microcapsules. Keywords Mesh Terms:

KEYWORDS: Surface-Active Agents

MESH TERMS: chemistry

Chemical & Substance for Abstract: Effect of surfactant on the characteristics of biodegradable microcapsules. Information

Substance Name: Lactic Acid

Registry Number: 50-21-5

Grant and Affiliation Information for Effect of surfactant on the characteristics of biodegradable microcapsules.

AFFILIATION: College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125-1098, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM08008-32

ACRONYM: GM

MEDLINETA: J Biomater Sci Polym Ed

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