[Effect of soy isoflavone on gene expression of leptin and insulin sensibility in insulin-resistant rats]

[Effect of soy isoflavone on gene expression of leptin and insulin sensibility in insulin-resistant rats] Research Abstract Details 

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[Effect of soy isoflavone on gene expression of leptin and insulin sensibility in insulin-resistant rats] Abstract Text:

Shi-wei Chen,Li-shi Zhang,Hong-min Zhang,Xiao-fan Feng,Xiao-li Peng,

OBJECTIVE: To explore the effects of soy isoflavone (SIF) on gene expression of leptin and insulin sensibility in insulin-resistant (IR) rats induced by high-fat, and to reveal the mechanisms of SIF in ameliorating insulin sensibility. METHODS: IR rats were randomly divided into four groups based on their insulin-resistant indexes (IRI): one model control group and three SIF groups that were gavaged with water solutions with SIF at doses of 0 mg/kg, 50 mg/kg, 150 mg/kg, and 450 mg/kg, respectively. After one month, fasting glucose, fasting insulin, leptin in serum, and leptin mRNA in the perirenal adipocyte were detected by enzymic method, radioimmunoassay, enzyme linked immunosorbent assay, and real time quantitative RT-PCR, respectively. RESULTS: The model control group was used to compare against the other groups: (1) Insulin and IRI were lower in the 150 mg/kg and 450 mg/kg groups; (2) In the 450 mg/kg group, body weight and leptin mRNA expression were lower, serum leptin content was higher. CONCLUSION: These results indicate that soy isoflavone might decrease body weight of rats and leptin mRNA, increase serum leptin level, and ameliorate leptin and insulin sensitivities.

[Effect of soy isoflavone on gene expression of leptin and insulin sensibility in insulin-resistant rats] Publishing Authors By Initials

SW Chen,LS Zhang,HM Zhang,XF Feng,XL Peng,

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[Effect of soy isoflavone on gene expression of leptin and insulin sensibility in insulin-resistant rats] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe

VOLUME: 38

Page Numbers: 197-200

Journal Abbreviation: Beijing Da Xue Xue Bao

ISSN: 1671-167X

DAY: 18

MONTH: Apr

YEAR: 2006

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LANGUAGE: chi

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AFFILIATION: Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China.

Country: China

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MEDLINETA: Beijing Da Xue Xue Bao

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