Effect of short-term outlet obstruction on rat bladder nerve density and contractility.

Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Research Abstract Details 

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Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Abstract Text:

M M Barendrecht,P Chichester,M C Michel,R M Levin,

1 The present study was designed to investigate the relationship between innervation density and contractile responses to field stimulation and exogenous agonists at early time points after induction of bladder outlet obstruction (BOO) in rats. 2 When compared with sham-operated animals, 1, 3 and 7 days of BOO were associated with a 75%, 80% and 90% increase of bladder weight. Field stimulation caused a frequency-dependent increase in force of contraction. The force of contraction was reduced at each frequency in BOO rats with the greatest decrease after 1 day and a gradual but incomplete recovery thereafter. In contrast, contractile responses to ATP, carbachol and KCl were markedly reduced after 1 day of BOO and fully recovered after 7 days. The neurofilament staining was not altered by 1 day of BOO, but gradually decreased with increasing duration of BOO reaching the lowest levels after 7 days. 3 We conclude that impaired cellular contractility seems to underlie the early reductions of field stimulation-induced contraction, possibly reflecting surgical trauma of the tissue. However, at later time points a reduced nerve density, possibly reflecting a partial denervation, appears to be the main reason for impaired contractile response to field stimulation.

Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Publishing Authors By Initials

MM Barendrecht,P Chichester,MC Michel,RM Levin,

For similar male urogenital diseases: urologic diseases: urethral diseases: urethral obstruction: urinary bladder neck obstruction research abstracts see: male urogenital diseases: urologic diseases: urethral diseases: urethral obstruction: urinary bladder neck obstruction research

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Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Autonomic & autacoid pharmacology

VOLUME: 27

Page Numbers: 47-53

Journal Abbreviation:

ISSN: 1474-8665

DAY: 3

MONTH: Jan

YEAR: 2007

Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101157306

Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder Neck Obstruction

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Information

Substance Name: Potassium Chloride

Registry Number: 7447-40-7

Grant and Affiliation Information for Effect of short-term outlet obstruction on rat bladder nerve density and contractility.

AFFILIATION: Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands.

Country: England

AGENCY: United States NIDDK

GRANT: R0-1-DK 067114

ACRONYM: DK

MEDLINETA: Auton Autacoid Pharmacol

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