Effect of senescence on macrophage polarization and angiogenesis.

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Effect of senescence on macrophage polarization and angiogenesis. Abstract Text:

Dru S Dace,Rajendra S Apte,

ABSTRACT There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.

Effect of senescence on macrophage polarization and angiogenesis. Publishing Authors By Initials

DS Dace,RS Apte,

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Effect of senescence on macrophage polarization and angiogenesis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Rejuvenation research

VOLUME: 11

Page Numbers: 177-85

Journal Abbreviation: Rejuvenation Res

ISSN: 1549-1684

DAY: 18

MONTH: Mar

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Department of Ophthalmology and Visual Sciences, Washington University, St. Louis School of Medicine, St. Louis, Missouri.

Country: United States

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MEDLINETA: Rejuvenation Res

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