[Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma]

[Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] Abstract Text:

Chuan-Gao Xie,Xing-Peng Wang,Yu-Wei Dong,Jian-Ting Cai,Ke-Da Qian,

BACKGROUND & OBJECTIVE: The previous study has identified that cyclooxygenase-2 (COX-2) may have a close relation with tumor genesis, particularly with digestive tract tumors, and its inhibitor can exert the chemoprevention role on carcinogenesis. This study was designed to investigate the effect of celebrex, a selective cyclooxygenase-2 inhibitor, on the expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma of xenografted nude mice induced by pancreatic carcinoma PC-3 cell lines. METHODS: The effect of celebrex on tumor growth was observed.The expression of VEGF in the tumors was determined by reverse transcription polymerase chain reaction (RT-PCR), Western blot analysis, and enzyme-linked immunosorbent assay (ELISA). RESULTS: Average tumor volume and tumor weight from control mice were 0.438+/-0.052 cm(3) and 0.552+/-0.064 g as compared with 0.215+/-0.038 cm(3) and 0.244+/-0.042 g from treated mice (inhibition rate:51.6%,P< 0.05). VEGF expression was significantly down-regulated in the celebrex-treated tumors. ELISA revealed that the expression levels of VEGF were 1.11+/-0.11(microg/g) in control mice and the 0.66+/-0.11(microg/g) in the treated mice. The inhibition rate of VEGF was 40.6% (P< 0.05). CONCLUSION: COX-2 may play an important role in the angiogenesis of pancreatic carcinoma. The selective COX-2 inhibitor, celebrex, can result in the inhibition of angiogenesis and tumor growth.

[Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] Publishing Authors By Initials

CG Xie,XP Wang,YW Dong,JT Cai,KD Qian,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Ai zheng = Aizheng = Chinese journal of cancer

VOLUME: 22

Page Numbers: 1042-6

Journal Abbreviation: Ai Zheng

ISSN: 1000-467X

DAY: 15

MONTH: Oct

YEAR: 2003

[Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9424852

[Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma]

AFFILIATION: Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University Medical College, Hangzhou, Zhejiang, 310009, PR China. xiechuangaosky@yahoo.com.cn

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Ai Zheng

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor VEGF in pancreatic carcinoma Related Publications

• Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma.
• Imaging Glucose-Regulated Insulin Secretion and Gene Expression in Single Islet beta-Cells: Control by AMP-Activated Protein Kinase.
• [A misdiagnosed case of imported falciparum malaria]
• [Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3]
• [Analysis on causes of death of childhood leukemia from 1981 to 2000 in the city of Tianjin]
• [Application of flow cytometry to detect PP65 antigenemia for diagnosis and monitoring of human cytomegalovirus infection]
• [Application of glycosyl fluorides in the study on glycosidases]
• [Biomechanical experiment of non-stemmed anatomical total hip prosthesis arthroplasty in vitro]
• [Clinical study on acute lung injury and adult respiratory distress synolrome]
• [Detection of WT1 expression in bone marrow of acute leukemia patients with real-time quantitative RT-PCR.]
• [Determination of methanol and ethanol in serum by gas chromatography.]
• [Determination of trace selenium in spirulina by continuous-flow hydride generation atomic absorption spectrometry]
• [Dynamic monitering of Ph positive cells during early post-transplant period in chronic granulocytic leukemia by interphase FISH]
• [Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma]
• [Effect of sodium iron chlorophyllin (SIC) on CFU-E and CFU-GM yields of normal and anemic animal models]
• [Effects of different doses of hydrocortisone on acute lung injury in rats with early septic shock induced by Escherichia coli]
• [Effects of external counterpulsation on the pulsatility of blood pressure and blood flow in dogs]
• [Effects of hydrocortisone on circulating and intramyocardial inflammatory mediators in severe septic rats with myocardial injury induced by Escherichia coli]
• [Hepatic failure after porta-systemic venous shunt in hepato-cirrhosis]
• [In Process Citation]
• [Iron, transferrin and transferrin receptor in the brain]
• [Micro-Raman and fluorescence spectra of several agrochemicals]
• [Multivariate analysis of prognostic factors in Philadelphia chromosome-positive chronic granulocytic leukemia]
• [Observation of long-term therapeutic outcome in chronic granulocytic leukemia]
• [Parainfluenza virus infections in pediatric patients with acute respiratory infections in Beijing during 2001 - 2003]
• [Rapid determination of trace Sb in plastic pipes for dringing water by GFAAS]
• [The evolutionary traits of mitocondrial ND4-ND4L in Drosophila melanogaster species group]
• [Three-dimensional finite element analysis of the biomechanical effects of multiloop edgewise archwire (MEAW)]
• [Value of blinded sampling methods in the pathogenic diagnosis of ventilator-associated pneumonia]
• [Vascular endothelial growth factor expression in focal cerebral ischemia/reperfusion in injury in rats]