Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice.

Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice. Research Abstract Details 

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Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice. Abstract Text:

Hiroki Fujita,Masafumi Kakei,Hiromi Fujishima,Tsukasa Morii,Yuichiro Yamada,Zhonghua Qi,Matthew D Breyer,Hiroki Fujita,Masafumi Kakei,Hiromi Fujishima,Tsukasa Morii,Yuichiro Yamada,Zhonghua Qi,Matthew D Breyer,Hiroki Fujita,Masafumi Kakei,Hiromi Fujishima,Tsukasa Morii,Yuichiro Yamada,Zhonghua Qi,Matthew D Breyer,

Previous studies have shown that Prostaglandin E(2) (PGE(2)) inhibits glucose-stimulated insulin secretion. However, the role of cyclooxygenase (COX)-1 vs. COX-2 derived PGE(2) production in glucose-stimulated insulin secretion remains poorly understood. Here we investigated the expression of COX-1 and COX-2 in pancreatic islets and the effect of selective inhibition of COX-1 and COX-2 on glucose-stimulated insulin secretion using C57BL/6 (B6) mice. Although immunofluorescence histochemistry showed the constitutive expression of both COX-1 and COX-2 in B6 mouse pancreatic islets, insulin secretion and hyperglycemia after glucose loading were ameliorated in B6 mice treated with selective COX-2 inhibitor (SC58236) for 18 weeks. Interestingly, incubation with selective COX-2 inhibitor for 24h led to a reduction in PGE(2) production in pancreatic islets isolated from B6 mice. In addition, selective COX-2 inhibition enhanced insulin secretion from the isolated islets. These results collectively suggest that selective inhibition of COX-2 enhances glucose-stimulated insulin secretion through a reduction in PGE(2) production in pancreatic islets.

Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice. Publishing Authors By Initials

H Fujita,M Kakei,H Fujishima,T Morii,Y Yamada,Z Qi,MD Breyer,H Fujita,M Kakei,H Fujishima,T Morii,Y Yamada,Z Qi,MD Breyer,H Fujita,M Kakei,H Fujishima,T Morii,Y Yamada,Z Qi,MD Breyer,

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Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 363

Page Numbers: 37-43

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 27

MONTH: 08

YEAR: 2007

Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice.

AFFILIATION: Division of Endocrinology, Metabolism and Geriatric Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. hirofuji@gipc.akita-u.ac.jp

Country: United States

AGENCY: United States NIDDK

GRANT: DK74116

ACRONYM: DK

MEDLINETA: Biochem Biophys Res Commun

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