Effect of rotavirus strain on the murine model of biliary atresia.

Effect of rotavirus strain on the murine model of biliary atresia. Research Abstract Details 

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Effect of rotavirus strain on the murine model of biliary atresia. Abstract Text:

Steven R Allen,Mubeen Jafri,Bryan Donnelly,Monica McNeal,David Witte,Jorge Bezerra,Richard Ward,Gregory M Tiao,

Biliary atresia is a devastating disorder of the newborn in which afflicted infants develop inflammation and fibrosis of the extrahepatic biliary tract, resulting in cirrhosis and end-stage liver disease. Infection with a virus is thought to be a contributing factor in the etiology of biliary atresia. In the murine model of biliary atresia, perinatal exposure to rhesus rotavirus (RRV) results in biliary epithelial cell infection causing bile duct obstruction. The purpose of this study was to determine if tropism for the biliary epithelial cell was unique to RRV. Newborn mice underwent intraperitoneal injection with five strains of rotavirus: RRV (simian), SA11-FM (simian/bovine), SA11-SM (simian), EDIM (murine), and Wa (human). RRV and SA11-FM caused clinical manifestations of bile duct obstruction and high mortality. SA11-SM caused clinical signs of hepatobiliary injury but the mortality was markedly reduced. EDIM and Wa caused no sign of hepatobiliary disease. The systemic and temporal distribution of viral protein and live virus varied according to the injected strain. Immunohistochemistry revealed that RRV and SA11-FM targeted the biliary epithelial cells. In contrast, SA11-SM was found in the liver but in not in the biliary epithelium. These results indicate that strain-specific characteristics dictate tropism for cells of hepatobiliary origin which in turn impact the ability to induce the murine model of biliary atresia.

Effect of rotavirus strain on the murine model of biliary atresia. Publishing Authors By Initials

SR Allen,M Jafri,B Donnelly,M McNeal,D Witte,J Bezerra,R Ward,GM Tiao,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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MEDLINE DATE:

Effect of rotavirus strain on the murine model of biliary atresia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 1671-9

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 22

MONTH: 11

YEAR: 2006

Effect of rotavirus strain on the murine model of biliary atresia. Information

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LANGUAGE: eng

NlmUniqueID: 113724

Effect of rotavirus strain on the murine model of biliary atresia. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effect of rotavirus strain on the murine model of biliary atresia. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Effect of rotavirus strain on the murine model of biliary atresia.

AFFILIATION: Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2923, Cincinnati, OH 45229, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: K08 DK0728858-01

ACRONYM: DK

MEDLINETA: J Virol

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