Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus.

Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Abstract Text:

Jean-Paul Albertini,Stephen O McMorn,Hongzi Chen,Richard A Mather,Paul Valensi,Jean-Paul Albertini,Stephen O McMorn,Hongzi Chen,Richard A Mather,Paul Valensi,Jean-Paul Albertini,Stephen O McMorn,Hongzi Chen,Richard A Mather,Paul Valensi,

The effect of the insulin sensitizer rosiglitazone (RSG) on biological markers of endothelial dysfunction in subjects with type 2 diabetes mellitus (T2DM) was investigated in a 12-week, multi-center, randomized, double-blind study. One hundred and thirty-six subjects aged 40-70 years, with FPG > or = 7.0 and < or = 15.0 mmol/l, previously treated with a single oral anti-diabetic agent or diet/exercise, were randomized to RSG 8 mg/day (n=65) or placebo (PBO, n=71). Results revealed that RSG significantly reduced soluble (s)E-selectin by -10.9% (P=0.004) compared with PBO, but did not significantly alter soluble vascular cell adhesion molecule-1 (+0.6%, P=NS). Compared with PBO, RSG also significantly reduced plasminogen activator inhibitor-1 (-36.9%, P<0.001), tissue plasminogen activator antigen (-22.7%, P<0.001), FPG (-2.8 mmol/l, P<0.001), fasting fructosamine (-42.0 mg/dl, P<0.001). Post-prandial AUC(0-4h) for free fatty acids (FFAs) reduced by -6.5 mg/dl*h from baseline (P=0.03), a change that positively and significantly correlated with changes in sE-selectin (r=0.22, P=0.05). The incidence of adverse events was similar in the two groups (RSG: 35.4%; PBO: 40.8%); the majority mild or moderate. These data support the hypothesis that, in patients with T2DM, rosiglitazone has beneficial effects on biological markers of endothelial dysfunction. Improvements in insulin sensitivity and decreases in FFAs may play a role in these effects.

Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Publishing Authors By Initials

JP Albertini,SO McMorn,H Chen,RA Mather,P Valensi,JP Albertini,SO McMorn,H Chen,RA Mather,P Valensi,JP Albertini,SO McMorn,H Chen,RA Mather,P Valensi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Atherosclerosis

VOLUME: 195

Page Numbers: e159-66

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 5

MONTH: 02

YEAR: 2007

Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 242543

Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus.

AFFILIATION: Laboratoire de Biochimie, Hôpital Avicenne AP-HP, Bobigny, France. jean-paul.albertini@avc.aphp.fr

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Atherosclerosis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus Related Publications

• Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus.
• Importance of observational studies in clinical practice.
• Importance of observational studies in clinical practice.
• Nerve electrophysiological changes in rats with early induced diabetes.
• [Not Available.]