Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans.

Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans. Research Abstract Details 

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Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans. Abstract Text:

Dan Nemet,Alon Eliakim,Frank Zaldivar,Dan M Cooper,

Exercise leads to simultaneous increases in mediators signaling apparently antagonistic functional responses such as growth factors and inflammatory mediators. The aim of the present study was to demonstrate the physiological effect of IL-6 on circulating components of the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis. Twelve men (ages 26 +/- 2 yr) were divided into two groups (n = 6 in each group), receiving either albumin or recombinant human (rh) IL-6 infusion. IL-6 was infused via an antecubital vein, and a contralateral antecubital vein was used for blood sampling. The IL-6 dose was chosen to reach plasma levels of IL-6 characteristic of intense exercise (5 microg/h, for 3 h, resulting in plasma levels of 100 pg/ml). Blood samples for GH, GH binding protein, IGF-I, and IGF binding protein (IGFBP)-1 and -3 were collected at baseline, 30 min, and 1, 2, 3, 4, 5, and 8 h after the beginning of the rhIL-6 infusion. IL-6 levels increased only in the rhIL-6-infused group (P < 0.0005) and returned to baseline after the infusion was stopped. IL-6 infusion led to a significant increase in GH, peaking 1 h after the beginning of infusion (P < 0.001). A decrease in total IGF-I levels was noted only in the rhIL-6-infused group (P < 0.027). An initial decrease in IGFBP-1 levels was noted in both groups during infusion (P < 0.03). Following the initial decrease, there was a significant increase in IGFBP-1 levels only in the IL-6-infused participants, peaking at 2 after the infusion cessation (P < 0.001). IL-6 infusion had no effect on GH binding protein, IGFBP-3, and acid-labile subunit levels. rhIL-6 levels similar to the levels found after strenuous exercise induced a typical exercise-associated GH-->IGF-I axis response (increase GH, decreased IGF-I, and elevated IGFBP-1). The results suggest that IL-6 plays a role in the GH-->IGF-I response to intense exercise.

Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans. Publishing Authors By Initials

D Nemet,A Eliakim,F Zaldivar,DM Cooper,

For similar proteins: recombinant proteins research abstracts see: proteins: recombinant proteins research

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Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Regulatory, integr

VOLUME: 291

Page Numbers: R1663-8

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 13

MONTH: 07

YEAR: 2006

Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans. Keywords Mesh Terms:

KEYWORDS: Recombinant Proteins

MESH TERMS: blood

Chemical & Substance for Abstract: Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans.

AFFILIATION: College of Medicine, Clinical Research Center, University of California at Irvine, 101 The City Drive, Orange, CA 92868, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M01 RR 00827

ACRONYM: RR

MEDLINETA: Am J Physiol Regul Integr Comp

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