Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats.

Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Research Abstract Details 

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Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Abstract Text:

B Banerjee,B K Medda,Z Lazarova,N Bansal,R Shaker,J N Sengupta,

A possible mechanism of oesophageal hypersensitivity is the acid-induced activation of transient receptor potential vanilloid receptor 1 (TRPV1) in the primary sensory neurons. We investigated TRPV1 expression and its colocalization with substance P (SP) and isolectin B4 (IB4)-positive cells in the thoracic dorsal root ganglia (DRGs) and nodose ganglia (NGs) of rats with reflux-induced oesophagitis (RO). RO was developed by fundus ligation and partial obstruction of the pylorus of Sprague-Dawley rats. Four groups of rats were used; fundus ligated acute (RO 48 h), chronic 7 days (RO 7D), RO 7D + omeprazole (7D + Omz, 40 mg kg(-1), i.p.) and sham-operated controls. Immunohistochemical analysis of TRPV1, SP and IB4 expression were carried out in spinal cord (SC), DRGs and NGs. RO rats exhibited significant inflammation and increase in TRPV1-ir and SP-ir expressions in the SC, DRGs and NGs. The maximum colocalization of TRPV1 and SP was observed in RO 7D rats, but Omz prevented inflammation and over expression of TRPV1 and SP. TRPV1-ir significantly increased in IB4-positive cells in DRGs and SC, but not in the NGs. Results document that acid-induced oesophagitis increases TRPV1 expression in both SP- and IB4-positive sensory neurons. The over expression of TRPV1 may contribute to oesophageal hypersensitivity observed in gastro-oesophageal reflux disease (GORD).

Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Publishing Authors By Initials

B Banerjee,BK Medda,Z Lazarova,N Bansal,R Shaker,JN Sengupta,

For similar proteins: carrier proteins: membrane transport proteins: ion channels: transient receptor potential channels: trpv cation channels research abstracts see: proteins: carrier proteins: membrane transport proteins: ion channels: transient receptor potential channels: trpv cation channels research

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Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurogastroenterology and motility : the official

VOLUME: 19

Page Numbers: 681-91

Journal Abbreviation: Neurogastroenterol. Motil.

ISSN: 1350-1925

DAY: 3

MONTH: Aug

YEAR: 2007

Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9432572

Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Keywords Mesh Terms:

KEYWORDS: TRPV Cation Channels

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Information

Substance Name: Substance P

Registry Number: 33507-63-0

Grant and Affiliation Information for Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats.

AFFILIATION: Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. banerjee@mcw.edu

Country: England

AGENCY: United States NIDDK

GRANT: R01 DK 25731

ACRONYM: DK

MEDLINETA: Neurogastroenterol Motil

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