Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice.

Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice. Research Abstract Details 

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Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice. Abstract Text:

Jing Li,Yunhai Liu,Jianguo Fang,Xin Chen,Wei Xie,

To investigate the effect of the anti-endotoxic part of Radix Isatidis on the expression of moesin mRNA in murine tissues induced by lipopolysaccharide (LPS), the sample solution of F(022) part from Radix Isatidis was intraperitoneally administered to experimental mice, and the lipopoly-saccharide (LPS) were injected into the tail vein, and then the tissues of liver, kidney and spleen were colleted and cut into slices. The mRNA was detected by moesin mRNA hybridization in situ. The staining results were observed under microscope. It was found that moesin mRNA expression was increased in the tissues of liver, kidndy and spleen in mice treated with LPS, while in the mice pre-treated with F(022) part from Radix Isatidis, the LPS-induced moesin mRNA expressions in these tissues were inhibited in a dose-dependant manner. Our study showed that F(022) part from Radix Isatidis can inhibit the LPS-induced expression of moesin mRNA in the tissues of liver, kidney and spleen in mice.

Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice. Publishing Authors By Initials

J Li,Y Liu,J Fang,X Chen,W Xie,

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Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 27

Page Numbers: 135-7

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 14

MONTH: Apr

YEAR: 2007

Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice. Information

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LANGUAGE: eng

NlmUniqueID: 101169627

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Grant and Affiliation Information for Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice.

AFFILIATION: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. xioxc@yahoo.com.cn

Country: China

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MEDLINETA: J Huazhong Univ Sci Technolog

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